N-甲基-3-苯基-3-羟基丙胺合成路线 （共 25 条）
反应条件
trifluorormethanesulfonic acid
参考文献
Klumpp; Aguirre; Sanchez Jr.; de Leon
Organic letters, 2001 , vol. 3, # 17 p. 2781 - 2784
反应条件
1: α-[2-(methylamino)ethyl]benzenemethanol With sodium hydride in dimethyl sulfoxide T=60°C; 1 h; Inert atmosphere; 2: 1-chloro-4-(trifluoromethyl)benzene in dimethyl sulfoxide T=100°C; 10 h; Inert atmosphere; 3: With water in diethyl ether; dimethyl sulfoxide
参考文献
Schulze, Matthias
Synthetic Communications, 2010 , vol. 40, # 22 p. 3415 - 3422
反应条件
tributylphosphine; di-isopropyl azodicarboxylate in dichloromethane; N,N-dimethyl acetamide T=70°C; Mitsunobu reaction; 0.0833333 h;
参考文献
Ahmed-Omer, Batoul; Sanderson, Adam J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 10 p. 3854 - 3862
反应条件
potassium hydroxide; tetra(n-butyl)ammonium hydrogen sulphate in sulfolane; water
参考文献
Albemarle Corporation
Patent: US5892117 A1, 1999 ;
反应条件
1: α-[2-(methylamino)ethyl]benzenemethanol With sodium t-butanolate in toluene T=0 - 20°C; 0.25 h; Inert atmosphere; 2: bis(4-trifluoromethylphenyl)iodonium tetrafluoroborate in toluene T=0 - 20°C; Inert atmosphere; chemoselective reaction;
参考文献
Ghosh, Raju; Lindstedt, Erik; Jalalian, Nazli; Olofsson, Berit
ChemistryOpen, 2014 , vol. 3, # 2 p. 54 - 57
