反应条件
1.1: sodium hydroxide / ethanol / 72 h / 0 - 22 °C
2.1: 1H-imidazole; 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 22 °C
2.2: 16 h / 22 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
4.1: water; sodium hydroxide / 16 h / 22 °C / Cooling with liquid nitrogen
View Scheme
参考文献
Ward, Richard A.; Brassington, Claire; Breeze, Alexander L.; Caputo, Alessandro; Critchlow, Susan; Davies, Gareth; Goodwin, Louise; Hassall, Giles; Greenwood, Ryan; Holdgate, Geoffrey A.; Mrosek, Michael; Norman, Richard A.; Pearson, Stuart; Tart, Jonathan; Tucker, Julie A.; Vogtherr, Martin; Whittaker, David; Wingfield, Jonathan; Winter, Jon; Hudson, Kevin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3285 - 3306