2-(1,2,3,6-四氢吡啶-4-基)-1,3-苯并噻唑合成路线 （共 5 条）
反应条件
1: 85 percent / dimethylsulfoxide / 200 °C
2: dimethylformamide / Heating
3: NaBH4 / ethanol / Ambient temperature
4: 1.) CH3CH(Cl)OCOCl, 2.) MeOH / 1.) CH2Cl2, 0 deg C, 2.) reflux
View Scheme
参考文献
Haworth; Harrison; Kulagowski; Leeson; Owens; Ridgill; Teall; Fielding; Chapman; Emms; Marwood; Patel; Moss
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2211 - 2216
反应条件
1: dimethylformamide / Heating
2: NaBH4 / ethanol / Ambient temperature
3: 1.) CH3CH(Cl)OCOCl, 2.) MeOH / 1.) CH2Cl2, 0 deg C, 2.) reflux
View Scheme
参考文献
Haworth; Harrison; Kulagowski; Leeson; Owens; Ridgill; Teall; Fielding; Chapman; Emms; Marwood; Patel; Moss
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2211 - 2216
反应条件
1: NaBH4 / ethanol / Ambient temperature
2: 1.) CH3CH(Cl)OCOCl, 2.) MeOH / 1.) CH2Cl2, 0 deg C, 2.) reflux
View Scheme
参考文献
Haworth; Harrison; Kulagowski; Leeson; Owens; Ridgill; Teall; Fielding; Chapman; Emms; Marwood; Patel; Moss
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2211 - 2216
反应条件
1: 85 percent / dimethylsulfoxide / 200 °C
2: dimethylformamide / Heating
3: NaBH4 / ethanol / Ambient temperature
4: 1.) CH3CH(Cl)OCOCl, 2.) MeOH / 1.) CH2Cl2, 0 deg C, 2.) reflux
View Scheme
参考文献
Haworth; Harrison; Kulagowski; Leeson; Owens; Ridgill; Teall; Fielding; Chapman; Emms; Marwood; Patel; Moss
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2211 - 2216
反应条件
methanol; 1-chloroethyl chlorocarbonate
1.) CH2Cl2, 0 deg C, 2.) reflux; Yield given. Multistep reaction;
参考文献
Haworth; Harrison; Kulagowski; Leeson; Owens; Ridgill; Teall; Fielding; Chapman; Emms; Marwood; Patel; Moss
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2211 - 2216
