4-(3,4-二氯苯基)-2-丁酮合成路线 （共 5 条）
反应条件
tetrabutylammonium chloride monohydrate; palladium diacetate; sodium carbonate in N,N-dimethyl-formamide
T=60°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; HU, Carol Hui; QIAO, Jennifer X.; WANG, Tammy C.
Patent: WO2013/151923 A1, 2013 ;
Location in patent: Paragraph 00173 ;
反应条件
in diethyl ether
T=0 - 20°C; 19 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ABELL, Lynn; ADAM, Leonard; CAVALLARO, Cullen L.; FINLAY, Heather; FRIENDS, Todd J.; HANGELAND, Jon J.; JIANG, Ji; LAWRENCE, R. Michael; LLOYD, John; PI, Zulan; TORA, George O.; QIAO, Jennifer X.; HU, Carol Hui; WANG, Tammy C.
Patent: WO2013/48982 A1, 2013 ;
Location in patent: Paragraph 00190 ;
反应条件
potassium carbonate in ethanol
参考文献
Rosowsky; Chen; Lin
Journal of medicinal chemistry, 1973 , vol. 16, # 3 p. 191 - 194
反应条件
1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C
2: diethyl ether / 19 h / 0 - 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ABELL, Lynn; ADAM, Leonard; CAVALLARO, Cullen L.; FINLAY, Heather; FRIENDS, Todd J.; HANGELAND, Jon J.; JIANG, Ji; LAWRENCE, R. Michael; LLOYD, John; PI, Zulan; TORA, George O.; QIAO, Jennifer X.; HU, Carol Hui; WANG, Tammy C.
Patent: WO2013/48982 A1, 2013 ;
反应条件
1: sodium hydroxide / water / 2 h / 20 °C
2: hydrogen; palladium 10 on activated carbon; 4,4'-diphenylsulfide / methanol / 24 h / 25 °C / 760.05 Torr
View Scheme
参考文献
COGNITION THERAPEUTICS, INC.; CATALANO, Susan, M.; RISHTON, Gilbert; IZZO, Nicholas, J.
Patent: WO2013/29057 A2, 2013 ;
