N1,1-二苯基-1,2-乙二胺合成路线 （共 8 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
0.25 h; Heating;
参考文献
Meij, Paul F. C. van der; Lohmann, Ruth D.; Waard, Eduard R. De; Chen, Tjoe B. R. A.; Pandit, Upendra K.
Tetrahedron, 1986 , vol. 42, # 14 p. 3921 - 3930
反应条件
acetic anhydride; platinum
Hydrogenation;
参考文献
Leonard et al.
Journal of Organic Chemistry, 1950 , vol. 15, p. 979,983
反应条件
1: 1.) 25percent aq. AcOH, NaHSO3 / 1.) 60 deg C, 1 h, 2.) 60 deg C, 3 d
2: H2, 2 N NH3 / Ra-Ni / methanol / 2585.7 Torr / Ambient temperature
View Scheme
参考文献
Maillard, Michel C.; Perlman, Michael E.; Amitay, Oved; Baxter, Deborah; Berlove, David; Connaughton, Sonia; Fischer, James B.; Guo, Jun Qing; Hu, Lain-Yen; McBurney, Robert N.; Nagy, Peter I.; Subbarao, Katragadda; Yost, Elizabeth A.; Zhang, Lu; Durant, Graham J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 16 p. 3048 - 3061
反应条件
1: 1.) 25percent aq. AcOH, NaHSO3 / 1.) 60 deg C, 1 h, 2.) 60 deg C, 3 d
2: H2, 2 N NH3 / Ra-Ni / methanol / 2585.7 Torr / Ambient temperature
View Scheme
参考文献
Maillard, Michel C.; Perlman, Michael E.; Amitay, Oved; Baxter, Deborah; Berlove, David; Connaughton, Sonia; Fischer, James B.; Guo, Jun Qing; Hu, Lain-Yen; McBurney, Robert N.; Nagy, Peter I.; Subbarao, Katragadda; Yost, Elizabeth A.; Zhang, Lu; Durant, Graham J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 16 p. 3048 - 3061
反应条件
in methanolic ammonia
参考文献
WARNER-LAMBERT COMPANY
Patent: EP432442 A1, 1991 ;
反应条件
1: 95 percent / glacial acetic acid / H2O / 0.5 h / 0 °C
2: H2, methanolic NH3 / Raney nickel / 1875.1 Torr / Ambient temperature
View Scheme
参考文献
Naim, S. Shawkat; Sharma, Satyavan
Synthesis, 1992 , # 7 p. 664 - 666
反应条件
1,4-diaza-bicyclo[2.2.2]octane in toluene
T=150 - 170°C; 2 h; Microwave irradiation;
参考文献
Gonzalez-Arellano, Camino; Yoshida, Kenta; Luque, Rafael; Gai, Pratibha L.
Green Chemistry, 2010 , vol. 12, # 7 p. 1281 - 1287
参考文献
Ingebrigtsen, Truls; Lejon, Tore
Heterocycles, 2007 , vol. 71, # 4 p. 891 - 902
