(R)-(+)-萘基-1-乙醇合成路线 （共 74 条）
反应条件
1,3-bis-[(R)-1-(1-naphthyl)ethyl]-4,5-dihydro-3H-imidazolium tetrafluoroborate; potassium tert-butylate in diethyl ether T=0°C; 24 h; Title compound not separated from byproducts;
参考文献
Suzuki, Yumiko; Muramatsu, Kazuyuki; Yamauchi, Kaori; Morie, Yasuko; Sato, Masayuki
Tetrahedron, 2006 , vol. 62, # 2-3 p. 302 - 310
反应条件
1,3-bis-[(R)-1-(1-naphthyl)ethyl]-4,5-dihydro-3H-imidazolium tetrafluoroborate; potassium tert-butylate in diethyl ether T=0°C; 24 h; Title compound not separated from byproducts;
参考文献
Suzuki, Yumiko; Muramatsu, Kazuyuki; Yamauchi, Kaori; Morie, Yasuko; Sato, Masayuki
Tetrahedron, 2006 , vol. 62, # 2-3 p. 302 - 310
反应条件
1: 83 percent / N-methylmorpholine N-oxide, OsO4 / H2O; various solvent(s) / 4 h / Ambient temperature 3: 60 percent / pyridine / 5 h / 0 - 5 °C 4: 81 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Naemura, Koichiro; Nishioka, Kazuyuki; Ogasahara, Kazuko; Nishikawa, Yasushi; Hirose, Keiji; Tobe, Yoshito
Tetrahedron Asymmetry, 1998 , vol. 9, # 4 p. 563 - 574
反应条件
1: 60 percent / pyridine / 5 h / 0 - 5 °C 2: 81 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Naemura, Koichiro; Nishioka, Kazuyuki; Ogasahara, Kazuko; Nishikawa, Yasushi; Hirose, Keiji; Tobe, Yoshito
Tetrahedron Asymmetry, 1998 , vol. 9, # 4 p. 563 - 574
反应条件
2: 60 percent / pyridine / 5 h / 0 - 5 °C 3: 81 percent / LiAlH4 / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Naemura, Koichiro; Nishioka, Kazuyuki; Ogasahara, Kazuko; Nishikawa, Yasushi; Hirose, Keiji; Tobe, Yoshito
Tetrahedron Asymmetry, 1998 , vol. 9, # 4 p. 563 - 574
反应条件
1: 1-(1-hydroxyethyl)naphthalene With (S,R(P))-2-phenyl-2,3-dihydroimidazo[1,2-a]pyrindinyl-pentaphenylcyclopentadienyliron; N-ethyl-N,N-diisopropylamine in toluene T=0°C; 0.0833333 h; 2: propionic acid anhydride in toluene T=0°C; 7 h; optical yield given as percent eeenantioselective reaction;
参考文献
Hu, Bin; Meng, Meng; Wang, Zheng; Du, Wenting; Fossey, John S.; Hu, Xinquan; Deng, Wei-Ping
Journal of the American Chemical Society, 2010 , vol. 132, # 47 p. 17041 - 17044
反应条件
(5aS,10bR)-5a,10b-dihydro-2-(pentafluorophenyl)-4H,6H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazinium tetrafluoroborate; 3-benzylriboflavin tetraacetate; triethylamine in toluene T=20°C; 4 h; Resolution of racemateAirMolecular sieve; optical yield given as percent eeenantioselective reaction;
参考文献
Iwahana, Soichiro; Iida, Hiroki; Yashima, Eiji
Chemistry - A European Journal, 2011 , vol. 17, # 29 p. 8009 - 8013
反应条件
{3-[2-(3,5-dimethylphenyl)naphthalen-1-yl]pyridin-4-yl}diethylamine; triethylamine in toluene T=-78°C; 2 h; optical yield given as percent ee;
参考文献
Larionov, Evgeny; Mahesh, Mohan; Spivey, Alan C.; Wei, Yin; Zipse, Hendrik
Journal of the American Chemical Society, 2012 , vol. 134, # 22 p. 9390 - 9399
反应条件
lipase from candida antartica in aq. phosphate buffer T=30°C; 48 h;
参考文献
Kataoka, Noriyuki; Okudomi, Masayuki; Chihara, Naoka; Matsumoto, Kazutsugu
Letters in Organic Chemistry, 2012 , vol. 9, # 9 p. 615 - 621
反应条件
lipase from candida antartica in aq. phosphate buffer T=30°C; 48 h;
参考文献
Kataoka, Noriyuki; Okudomi, Masayuki; Chihara, Naoka; Matsumoto, Kazutsugu
Letters in Organic Chemistry, 2012 , vol. 9, # 9 p. 615 - 621
