5-氯-2-甲基苯并呋喃合成路线 （共 12 条）
反应条件
1: N-bromosuccinimide, AIBN / CCl4 / 24 h / Heating 2: KOH, n-Bu4NHSO4 / CHCl3; H2O / 1.) RT, 1 h, 2.) reflux, 30 min View Scheme
参考文献
Ellingboe; Alessi; Dolak; Nguyen; Tomer; Guzzo; Bagli; McCaleb
Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1176 - 1183
反应条件
1: With N,N-diethylaniline
T=210°C;
2: With hydrogenchloride in water
T=85°C; 8 h;
参考文献
ELI LILLY AND COMPANY
Patent: EP1266897 A2, 2002 ;
Location in patent: Page 38 ;
反应条件
sulfuric acid in ethanol
3 h; Heating;
参考文献
Alemagna, Andreina; Baldoli, Clara; Buttero, Paola Del; Licandro, Emanuela; Maiorana, Stefano
Synthesis, 1987 , # 2 p. 192 - 196
反应条件
chromium dichloride; boron trifluoride diethyl etherate in tetrahydrofuran
Heating;
参考文献
Ledoussal, Benoit; Gorgues, Alain; Coq, Andre Le
Journal of the Chemical Society, Chemical Communications, 1986 , # 2 p. 171 - 172
反应条件
T=650°C; P=0.001 - 0.01 Torr;
参考文献
Black, Michael; Cadogan, J. I. G.; Cartwright, Gary A.; McNab, Hamish; MacPherson, Andrew D.
Journal of the Chemical Society, Chemical Communications, 1993 , # 11 p. 959 - 960
反应条件
T=650°C; P=0.01 Torr; 0.333333 h;
参考文献
Black, Michael; Cadogan; McNab, Hamish; MacPherson, Andrew D.; Roddam, V. Peter; Smith, Carol; Swenson, Helen R.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 17 p. 2483 - 2493
反应条件
hydrogenchloride in 2-methoxy-ethanol
4 h; Heating;
参考文献
Ota, Tomomi; Hasegawa, Shun; Inoue, Seiichi; Sato, Kikumasa
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3029 - 3036
反应条件
sodium acetate; acetic anhydride
参考文献
Ando, Kumiko; Kawamura, Yoko; Akai, Yukiko; Kunitomo, Jun-Ichi; Yokomizo, Takehiko; Yamashita, Masayuki; Ohta, Shunsaku; Ohishi, Takahiro; Ohishi, Yoshitaka
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 2 p. 296 - 307
反应条件
1: CH2Cl2
2: 93 percent / K2CO3 / dimethylformamide / 1.) 5 min, 2.) overnight
3: 85 percent / 0.33 h / 650 °C / 0.01 Torr
View Scheme
参考文献
Black, Michael; Cadogan; McNab, Hamish; MacPherson, Andrew D.; Roddam, V. Peter; Smith, Carol; Swenson, Helen R.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 17 p. 2483 - 2493
反应条件
1: 93 percent / K2CO3 / dimethylformamide / 1.) 5 min, 2.) overnight
2: 85 percent / 0.33 h / 650 °C / 0.01 Torr
View Scheme
参考文献
Black, Michael; Cadogan; McNab, Hamish; MacPherson, Andrew D.; Roddam, V. Peter; Smith, Carol; Swenson, Helen R.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 17 p. 2483 - 2493
