1,12-二乙酰氧基十二烷合成路线 （共 18 条）
反应条件
1: 65 percent / ethyl acetate / 450 - 470 °C / quartz tube packed with glass 2: 98 percent / KOH / methanol; H2O / 8 h / Heating 3: 90 percent / bromine / CCl4 / 0.5 h / 20 °C 4: 75 percent / 18-crown-6-ether, KOH / petroleum ether / 10 h / 90 - 110 °C 5: 1) n-BuLi / 1) benzene + THF, 20 deg C, 1 h; 2) HMPTA, 20 deg C, 6 h. View Scheme
参考文献
Zakharkin, L. I.; Guseva, V. V.
Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 733 - 736
Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 776 - 779
反应条件
1: 65 percent / ethyl acetate / 450 - 470 °C / quartz tube packed with glass 2: 98 percent / KOH / methanol; H2O / 8 h / Heating 3: 90 percent / bromine / CCl4 / 0.5 h / 20 °C 4: 75 percent / 18-crown-6-ether, KOH / petroleum ether / 10 h / 90 - 110 °C 5: 1) n-BuLi / 1) benzene + THF, 20 deg C, 1 h; 2) HMPTA, 20 deg C, 6 h. 6: 97 percent / LiAlH4 / tetrahydrofuran; bis-(2-methoxy-ethyl) ether / 10 h / 140 °C View Scheme
参考文献
Zakharkin, L. I.; Guseva, V. V.
Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 733 - 736
Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 776 - 779
反应条件
1: 65 percent / ethyl acetate / 450 - 470 °C / quartz tube packed with glass
2: 98 percent / KOH / methanol; H2O / 8 h / Heating
3: 90 percent / bromine / CCl4 / 0.5 h / 20 °C
4: 75 percent / 18-crown-6-ether, KOH / petroleum ether / 10 h / 90 - 110 °C
5: 1) n-BuLi / 1) benzene + THF, 20 deg C, 1 h; 2) HMPTA, 20 deg C, 6 h.
6: 95 percent / hydrogen, quinoline / 5percent Pd/BaSO4 / hexane / 20 °C
View Scheme
参考文献
Zakharkin, L. I.; Guseva, V. V.
Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 733 - 736
Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 776 - 779
反应条件
1: 65 percent / ethyl acetate / 450 - 470 °C / quartz tube packed with glass
2: 98 percent / KOH / methanol; H2O / 8 h / Heating
3: 90 percent / bromine / CCl4 / 0.5 h / 20 °C
4: 75 percent / 18-crown-6-ether, KOH / petroleum ether / 10 h / 90 - 110 °C
View Scheme
参考文献
Zakharkin, L. I.; Guseva, V. V.
Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 733 - 736
Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 776 - 779
反应条件
HY-Zeolite in methanol
5 h; Heating;
参考文献
Srinivas; Mahender; Das, Biswanath
Synlett, 2003 , # 15 p. 2419 - 2421
反应条件
1: 65 percent / ethyl acetate / 450 - 470 °C / quartz tube packed with glass
2: 98 percent / KOH / methanol; H2O / 8 h / Heating
3: 90 percent / bromine / CCl4 / 0.5 h / 20 °C
4: 75 percent / 18-crown-6-ether, KOH / petroleum ether / 10 h / 90 - 110 °C
5: 1) lithium amide / 1) THF, 30-35 deg C, 0.5 h; 2) HMPTA, 20 deg C, 2 h.
View Scheme
参考文献
Zakharkin, L. I.; Guseva, V. V.
Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 733 - 736
Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 776 - 779
反应条件
1: 65 percent / ethyl acetate / 450 - 470 °C / quartz tube packed with glass
2: 12.8 g / bromine / CCl4 / 0.5 h / 0 - 1 °C
View Scheme
参考文献
Zakharkin, L. I.; Guseva, V. V.
Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 733 - 736
Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 776 - 779
反应条件
in ethyl acetate
T=450 - 470°C; quartz tube packed with glass;
参考文献
Zakharkin, L. I.; Guseva, V. V.
Chemistry of Natural Compounds, 1984 , vol. 20, # 6 p. 733 - 736
Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 6 p. 776 - 779
