3-(4-甲基苯基)-1-苯基-丙-2-烯-1-酮合成路线 （共 36 条）
反应条件
hydrogenchloride; bromine; sodium methylate
1.) CHCl3, ice water bath, then 30 min, room t., 2.) MeOH, reflux, 1 h, 3.) MeOH, reflux, 15 min; Multistep reaction;
参考文献
Hasegawa, Eietsu; Ishiyama, Kenyuki; Horaguchi, Takaaki; Shimizu, Takahachi
Journal of Organic Chemistry, 1991 , vol. 56, # 4 p. 1631 - 1635
反应条件
1.1: oxygen; sodium acetate / ethanol / 20 °C / |Schlenk technique
1.2: |Schlenk technique
2.1: oxygen; iron tribromide / toluene / 4 h / 110 °C / |Schlenk technique; |Sealed tube
View Scheme
参考文献
Zhang, Tianshui; Bao, Weiliang
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 1317 - 1322
反应条件
1: 1.)n-butyllithium, 2.) cuprous iodide / 1.) THF, -70 gradC, 1h, 1h, 2.) -70 gradC, 2h
2: 80 percent / cupric chloride, cupric oxide / acetone; H2O / 1 h / 25 - 30 °C
3: 95 percent / ammonium acetate / acetic acid / 5 h / 130 °C
View Scheme
参考文献
Nagarajan, M.; Shechter, H.
Journal of Organic Chemistry, 1984 , vol. 49, p. 62 - 74
反应条件
in chlorobenzene
T=105°C; 0.0833333 h; microwave irradiation;
参考文献
Veverkova, Eva; Noskova, Marika; Toma, Stefan
Synthetic Communications, 2002 , vol. 32, # 18 p. 2903 - 2910
反应条件
T=122°C; 0.0388889 h; microwave irradiation;
参考文献
Veverkova, Eva; Noskova, Marika; Toma, Stefan
Synthetic Communications, 2002 , vol. 32, # 18 p. 2903 - 2910
反应条件
dimethyl sulfoxide
T=20°C; Michael addition; 12 h; Inert atmosphereMolecular sieve;
参考文献
Kakinuma, Tomoko; Chiba, Ryoichi; Oriyama, Takeshi
Chemistry Letters, 2008 , vol. 37, # 12 p. 1204 - 1205
反应条件
copper(l) iodide; n-butyllithium
1.) THF, -70 gradC, 1h, 1h, 2.) -70 gradC, 2h; Yield given. Multistep reaction;
参考文献
Nagarajan, M.; Shechter, H.
Journal of Organic Chemistry, 1984 , vol. 49, p. 62 - 74
反应条件
samarium in N,N-dimethyl-formamide
T=25°C; Michael addition; 1.5 h; Inert atmosphere;
参考文献
Liu, Yongjun; Li, Yuanying; Qi, Yan; Wan, Jun
Synthesis, 2010 , # 24 art. no. F12610SS, p. 4188 - 4192
反应条件
1: 1.)n-butyllithium, 2.) cuprous iodide / 1.) THF, -70 gradC, 1h, 1h, 2.) -70 gradC, 2h
2: 80 percent / cupric chloride, cupric oxide / acetone; H2O / 1 h / 25 - 30 °C
View Scheme
参考文献
Nagarajan, M.; Shechter, H.
Journal of Organic Chemistry, 1984 , vol. 49, p. 62 - 74
反应条件
1: 70 percent perchloric acid / 1) 2 h, 90 deg C, 2) ethanol, 1 h, reflux
2: 66 percent / 25 percent aq. NH3 / ethanol / Heating
View Scheme
参考文献
Fischer, Gerhard W.; Zimmermann, Thomas; Weissenfels, Manfred
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 5 p. 729 - 741
