2-氯-8-甲基喹啉合成路线

参考文献

ARRAY BIOPHARMA INC.; COOK, Adam; HUNT, Kevin, W.; DELISLE, Robert Kirk; ROMOFF, Todd; CLARK, Christopher, T.; KIM, Ganghyeok; CORRETTE, Christopher, P.; DOHERTY, George, A.; BURGESS, Laurence, E.
Patent: WO2010/75200 A1, 2010 ;
Location in patent: Page/Page column 90-91 ;
WO 2010/075200 A1

4053-36-58-甲基-2(1H)-喹啉酮

4225-85-82-氯-8-甲基喹啉

参考文献

AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2011/143365 A1, 2011 ;
Location in patent: Page/Page column 183 ;
WO 2011/143365 A1

95-53-4邻甲苯胺

4225-85-82-氯-8-甲基喹啉

参考文献

AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2011/143365 A1, 2011 ;
WO 2011/143365 A1

78987-21-0

4225-85-82-氯-8-甲基喹啉

参考文献

AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2011/143365 A1, 2011 ;
WO 2011/143365 A1

35359-35-41,8-二甲基喹啉-2(1h)-酮+

10026-13-8五氯化磷+

10025-87-3三氯氧磷

4225-85-82-氯-8-甲基喹啉

参考文献

Fischer,O.
Chemische Berichte, 1902 , vol. 35, p. 3682

4225-85-82-氯-8-甲基喹啉

4053-36-58-甲基-2(1H)-喹啉酮

参考文献

Blankenstein; Capps
Journal of the American Chemical Society, 1954 , vol. 76, p. 3211

4225-85-82-氯-8-甲基喹啉+

124-41-4甲醇钠

4053-36-58-甲基-2(1H)-喹啉酮+

885687-65-02-甲氧基-8-甲基喹啉

参考文献

Spaeth
Monatshefte fuer Chemie, 1919 , vol. 40, p. 138
Monatshefte fuer Chemie, 1921 , vol. 42, p. 263

4225-85-82-氯-8-甲基喹啉+

124-41-4甲醇钠

885687-65-02-甲氧基-8-甲基喹啉

参考文献

Spaeth
Monatshefte fuer Chemie, 1919 , vol. 40, p. 138
Monatshefte fuer Chemie, 1921 , vol. 42, p. 263

4225-85-82-氯-8-甲基喹啉+

124-41-4甲醇钠

4053-36-58-甲基-2(1H)-喹啉酮+

885687-65-02-甲氧基-8-甲基喹啉

参考文献

Spaeth
Monatshefte fuer Chemie, 1919 , vol. 40, p. 138
Monatshefte fuer Chemie, 1921 , vol. 42, p. 263