N-甲基-N-乙基氨基甲酰氯合成路线 （共 9 条）
反应条件
sodium hydrogencarbonate in dichloromethane T=10 - 20°C; 3 h; Product distribution / selectivity;
参考文献
GENERICS [UK] LIMITED; MERCK DEVELOPMENT CENTER PRIVATE LIMITED
Patent: WO2007/80430 A1, 2007 ;
Location in patent: Page/Page column 12; 13 ;
反应条件
1: With chlorine in dichloromethane T=24 - 26°C; 6.33333 h; Cooling with ice; 2: With water; sodium hydrogencarbonate in dichloromethane Cooling with ice;
参考文献
Adeppa; Rupainwar; Misra, Krishna
Synthetic Communications, 2011 , vol. 41, # 2 p. 285 - 290
反应条件
1: in dichloromethane T=40°C; 3 h; Inert atmosphere; 2: With chlorine in dichloromethane T=20°C; 2 h;
参考文献
Adeppa; Rupainwar; Misra, Krishna
Canadian Journal of Chemistry, 2010 , vol. 88, # 12 p. 1277 - 1280
反应条件
in 1,4-dioxane T=55 - 60°C; 4 h;
参考文献
Hansen; Faarup; Bundgaard
Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 8 p. 793 - 798
反应条件
triethylamine in toluene Heating;
参考文献
Prozorovskii, V. B.; Pavlova, L. V.; Suslova, I. M.; Belozerova, L. V.; Kokushkina, A. V.; Sazonova, A. V.
Russian Journal of Applied Chemistry, 1995 , vol. 68, # 4.2 p. 589 - 593
Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation), 1995 , vol. 68, # 4 p. 675 - 679
反应条件
potassium carbonate in acetonitrile T=70 - 80°C;
参考文献
EMCURE PHARMACEUTICALS LIMITED
Patent: WO2006/48720 A1, 2006 ;
Location in patent: Page/Page column 4; 11 ;
反应条件
potassium carbonate in ethyl acetate Inert atmosphereRefluxLarge scale;
参考文献
Yan, Pu-Cha; Zhu, Guo-Liang; Xie, Jian-Hua; Zhang, Xiang-Dong; Zhou, Qi-Lin; Li, Yuan-Qiang; Shen, Wen-He; Che, Da-Qing
Organic Process Research and Development, 2013 , vol. 17, # 2 p. 307 - 312
反应条件
1: NAP 226-90 With sodium hydride in diethyl ether T=20°C; 1 h; 2: N-ethyl-N-methyl carbamoylchloride T=20°C; 3 h; Reactivity;
参考文献
ZENTIVA, A.S.
Patent: WO2004/37771 A1, 2004 ;
Location in patent: Page 13 ;
参考文献
Shionogi and Co., Ltd.
Patent: US4183856 A1, 1980 ;
