3-(2-氯乙基)-吡啶盐酸盐合成路线 （共 5 条）
反应条件
thionyl chloride in chloroform
15 h;
参考文献
Bagley; Thomas; Rudo; Spencer; Doorley; Ossipov; Jerussi; Benvenga; Spaulding
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 827 - 841
反应条件
sodium hydrogencarbonate
参考文献
Eisai Co., Ltd.
Patent: US4977165 A1, 1990 ;
反应条件
1.1: thionyl chloride / 2.5 h / Inert atmosphere; Reflux
2.1: sodium tetrahydroborate / methanol / 3.5 h / Inert atmosphere; Reflux
2.2: 20 °C
3.1: thionyl chloride / chloroform / 3 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Mitsubishi Chemical Corporation
Patent: EP2390243 A1, 2011 ;
反应条件
1.1: sodium tetrahydroborate / methanol / 3.5 h / Inert atmosphere; Reflux
1.2: 20 °C
2.1: thionyl chloride / chloroform / 3 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Mitsubishi Chemical Corporation
Patent: EP2390243 A1, 2011 ;
反应条件
1.1: ethanol; water / 4 h / Inert atmosphere; Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere; Cooling with ice
2.2: Cooling with ice
View Scheme
参考文献
Mitsubishi Chemical Corporation
Patent: EP2390243 A1, 2011 ;
