Alkaline conditions;

1: 1.) n-BuLi / 1.) a) THF, hexane, -78 deg C, b) -10 deg C, 30 min, 2.) RT, 1 h 2: 6 N HCl / tetrahydrofuran / 4 h / Heating View Scheme

1: triethylamine / tetrahydrofuran / 0 °C 2: 1.) n-BuLi / 1.) a) THF, hexane, -78 deg C, b) -10 deg C, 30 min, 2.) RT, 1 h 3: 6 N HCl / tetrahydrofuran / 4 h / Heating View Scheme

Alkaline conditions;