5-甲基-4-己烯酸乙酯合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Flachsbarth, Birte; Fritzsche, Matthias; Weldon, Paul J.; Schulz, Stefan
Chemistry and Biodiversity, 2009 , vol. 6, # 1 p. 1 - 37
反应条件
1: water; sodium hydroxide / ethanol / 12 h / Reflux 2: triethylamine; dicyclohexyl-carbodiimide / chloroform / 4 h 3: tetrahydrofuran / 3 h View Scheme
参考文献
Wang, Guan; Zou, Yue; Li, Zhiming; Wang, Quanrui; Goeke, Andreas
Journal of Organic Chemistry, 2011 , vol. 76, # 14 p. 5825 - 5831
反应条件
tert.-butylhydroperoxide; cobalt(II) dipivaloylmetanate; phenyl silane in decane; 1,2-dichloro-ethane; isopropyl alcohol Inert atmosphere; chemoselective reaction;
参考文献
Iwasaki, Kotaro; Wan, Kanny K.; Oppedisano, Alberto; Crossley, Steven W. M.; Shenvi, Ryan A.
Journal of the American Chemical Society, 2014 , vol. 136, # 4 p. 1300 - 1303
反应条件
tin(IV) chloride in dichloromethane
T=-20°C; 0.5 h;
参考文献
Ishibashi, Hiroyuki; Nakatani, Hiroshi; So, Taru Su; Fujita, Toyokazu; Ikeda, Masazumi
Heterocycles, 1990 , vol. 31, # 2 p. 215 - 218
反应条件
1: With diisobutylaluminium hydride in hexane; dichloromethane
T=-78°C; 0.45 h; Inert atmosphere;
2: With water in methanol; hexane; dichloromethane
T=-78 - 20°C; 2 h; Inert atmosphere;
参考文献
Rueda-Becerril, Montserrat; Leung, Joe C.T.; Dunbar, Christine R.; Sammis, Glenn M.
Journal of Organic Chemistry, 2011 , vol. 76, # 19 p. 7720 - 7729
反应条件
1: 86 percent / LAH / tetrahydrofuran / 1 h / Ambient temperature
2: triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 30 min
View Scheme
参考文献
Becker; Haddad
Tetrahedron, 1993 , vol. 49, # 4 p. 947 - 964
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
0.5 h; Ambient temperature;
参考文献
Coppola, Gary M.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1589 - 1591
反应条件
1: 1.) LDA, 3.) NaOH
2: 66 percent / DDQ / benzene / 2 h / Heating
View Scheme
参考文献
Kamikawa, Tadao; Hanaoka, Yasuyuki; Fujie, Satoru; Saito, Ken; Yamagiwa, Yoshiro; Fukuhara, Katsuya; Kubo, Isao
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 8 p. 1317 - 1320
反应条件
sodium hydroxide in ethanol
6 h; Heating;
参考文献
Cermak, Diana M.; Wiemer, David F.; Lewis, Kriste; Hohl, Raymond J.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 12 p. 2729 - 2737
反应条件
Multi-step reaction with 3 steps 1: 1.) NaH / 2.) THF, 2 h2: 1.) trifluoroacetic anhydride / 1.) CH2Cl2, 0 deg C, 1 h; 2.) room temp., 4 h3: 1.) NaIO4; 2.) NaHCO3 / 1.) H2O, MeOH, room temp., overnight; 2.) toluene, reflux, 3 h
参考文献
Ishibashi, Hiroyuki; Harada, Suzumi; Okada, Motofumi; Ikeda, Masazumi; Ishiyama, Ko-ichi; et al. Synthesis, 1986 , # 10 p. 847 - 849
