2,4-二氨基-5-羟甲基嘧啶合成路线 （共 9 条）
反应条件
1: With sodium tetrahydroborate in methanol T=20°C; 2: With water in methanol Cooling;
参考文献
Karoli, Tomislav; Mamidyala, Sreeman K.; Zuegg, Johannes; Fry, Scott R.; Tee, Ernest H.L.; Bradford, Tanya A.; Madala, Praveen K.; Huang, Johnny X.; Ramu, Soumya; Butler, Mark S.; Cooper, Matthew A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2428 - 2433
反应条件
1: H2; aq. HCl / Pd/C / 3 h / 60 °C / 3150.25 Torr 2: aq. NaBH4 View Scheme
参考文献
Otzen, Thomas; Wempe, Ellen G.; Kunz, Brigitte; Bartels, Rainer; Lehwark-Yvetot, Gudrun; Haensel, Wolfram; Schaper, Klaus-Juergen; Seydel, Joachim K.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 240 - 253
反应条件
1: 3.1 percent / glacial HOAc, HCl(g) / H2O / Heating 2: 1) NaH / 1) DMF, 0 deg C, 25 min, 2) DMF, RT, 2 h 3: H2 / 5percent Pd/c / ethanol View Scheme
参考文献
Roth; Tidwell; Ferone; Baccanari; Sigel; DeAngelis; Elwell
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1949 - 1958
反应条件
hydrogenchloride; anhydrous sodium hydrogen carbonate in water; acetic acid; acetone
参考文献
Burroughs Wellcome Co.
Patent: US4116958 A1, 1978 ;
反应条件
hydrogenchloride in ethylene glycol
T=110 - 115°C; 6 h;
参考文献
Roth; Rauckman; Ferone; Baccanari; Champness; Hyde
Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 348 - 356
反应条件
1: conc. HCl, glacial HOAc / Heating
2: 55 percent / 20percent Pd-C / various solvent(s) / 21 h / 150 °C
View Scheme
参考文献
Rauckman; Tidwell; Johnson; Roth
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1927 - 1935
反应条件
1: 1) conc. HCl, glacial HOAc, 2) 2N NaOH / 1) 6 h, reflux, 2) 6 h, reflux
2: 5.9 percent / conc. HCl, FeCl3*H2O / ethanol / 6 h / Heating
View Scheme
参考文献
Rauckman; Tidwell; Johnson; Roth
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1927 - 1935
反应条件
1: conc. HCl, glacial HOAc / Heating
2: 55 percent / 20percent Pd-C / various solvent(s) / 21 h / 150 °C
3: 53 percent / conc. H2SO4, HNO3 / 1) 0 to 5 deg C, 30 min, 2) 25 deg C, 1 h
View Scheme
参考文献
Rauckman; Tidwell; Johnson; Roth
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1927 - 1935
反应条件
hydrogenchloride; acetic acid in water
参考文献
Burroughs Wellcome Co.
Patent: US4568744 A1, 1986 ;
