1: KOH / acetone / 0.33 h / Heating 2: 60 mg / aq. NaOH / ethanol / 0.17 h / Heating 3: 293 mg / Et3N / CH2Cl2 / 0.5 h / 20 °C 4: 81 percent / Bu3P; 1,3-bis-(diphenylphosphino)propane; iPr2NEt / Pd(OAc)2 / dimethylformamide / 0.5 h / Heating View Scheme

1: KOH / acetone / 0.33 h / Heating 2: 60 mg / aq. NaOH / ethanol / 0.17 h / Heating 3: 578 mg / Et3N / CHCl3 / 12 h / 20 °C 4: 93 percent / Bu3P; 1,3-bis-(diphenylphosphino)propane; iPr2Net / Pd(OAc)2 / dimethylformamide / 0.5 h / Heating View Scheme