4H-1-苯并吡唑-4-酮合成路线 （共 29 条）
反应条件
1: NaH / ethanol; diethyl ether / 0 °C 2: TsN3, Et3N / CH2Cl2 / Ambient temperature 3: 90 percent / BF3*Et2O / CH2Cl2 / 1.5 h / Ambient temperature View Scheme
参考文献
Mandal, Pranab; Venkateswaran, Ramanathapuram V.
Journal of Chemical Research - Part S, 1998 , # 2 p. 88 - 89
反应条件
pyridine hydrochloride T=180 - 190°C; 2 h;
参考文献
Siddaiah, Vidavalur; Rao, Chunduri Venkata; Venkateswarlu, Somepalli; Krishnaraju, Alluri V.; Subbaraju, Gottumukkala V.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2545 - 2551
反应条件
1: 74 percent / CuBr2 / CHCl3; ethyl acetate / 3 h / Heating 2: 62 percent / tetrahydrofuran 3: 85 percent / pyridine / CHCl3 / 8 h / 60 °C 4: 1) dimethyldioxirane / 1) acetone, 15 min, RT, 2) toluene, reflux, 2 h View Scheme
参考文献
Donnelly, Dervilla M.; Finet, Jean-Pierre; Rattigan, Bernard A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 15 p. 1729 - 1736
反应条件
palladium (II) trifluoroacetate; Cu(TFA)2*xH2O; silver(I) acetate T=100°C; Heck Reaction; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Angewandte Chemie, International Edition, , vol. 51, # 45 p. 11333 - 11336,4
反应条件
1: 1.) n-BuLi, diisopropylamine / 1.) THF, hexane, 15 min, 2.) THF, hexane, 10 h
2: 85 percent / LAH / diethyl ether / 1 h / 0 °C
3: 60 percent / p-TsOH / benzene / 3 h / Ambient temperature
View Scheme
参考文献
Engler, Thomas A.; LaTessa, Kenneth O.; Iyengar, Rajesh; Chai, Wenying; Agrios, Konstantinos
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 10 p. 1755 - 1769
反应条件
1: 74 percent / CuBr2 / CHCl3; ethyl acetate / 3 h / Heating
2: 62 percent / tetrahydrofuran
3: 58 percent / pyridine / CHCl3 / 8 h / 60 °C
4: 1) dimethyldioxirane / 1) acetone, 15 min, RT, 2) toluene, reflux, 2 h
View Scheme
参考文献
Donnelly, Dervilla M.; Finet, Jean-Pierre; Rattigan, Bernard A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 15 p. 1729 - 1736
反应条件
3: 58.7 percent
4: 72.9 percent
5: 78.8 percent
6: 78.5 percent / MCPBA (70percent) / CH2Cl2 / 2 h / 0 °C
7: 1.) magnesium methoxide / 1.) methanol, rt., 16 h; 2.) benzene, reflux, 3 h
8: 61.3 percent / acetic acid / 1 h / Heating
View Scheme
参考文献
Ozaki, Yutaka; Mochida, Keiko; Kim, Sang-Won
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 5 p. 1790 - 1795
反应条件
1: 74 percent / CuBr2 / CHCl3; ethyl acetate / 3 h / Heating
2: 62 percent / tetrahydrofuran
3: 63 percent / pyridine / CHCl3 / 8 h / 60 °C
4: 1) dimethyldioxirane / 1) acetone, 15 min, RT, 2) toluene, reflux, 2 h
View Scheme
参考文献
Donnelly, Dervilla M.; Finet, Jean-Pierre; Rattigan, Bernard A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 15 p. 1729 - 1736
反应条件
1: 62 percent / pyridine hydrochloride / 2 h / 180 - 190 °C
2: 68 percent / perchloric acid; silica gel / 0.5 h / 90 - 100 °C
3: 42 percent / benzene / 4 h / Irradiation
View Scheme
参考文献
Siddaiah, Vidavalur; Rao, Chunduri Venkata; Venkateswarlu, Somepalli; Krishnaraju, Alluri V.; Subbaraju, Gottumukkala V.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2545 - 2551
