2,3-二氢-5-氯吲哚酮合成路线 （共 18 条）
反应条件
1: With ammonium acetate in isopropyl alcohol T=20°C; 1 h; 2: With sodium cyanoborohydride in isopropyl alcohol 2 h; Heating; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 3 p. 392 - 395
反应条件
sodium tetrahydroborate in methanol; 1,2-dichloro-ethane 0.5 h;
参考文献
Journal of the American Chemical Society, , vol. 127, # 30 p. 10482 - 10483
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: EP277384 A3, 1990 ;
反应条件
sodium hydride; tert-butyl alcohol in tetrahydrofuran
Heating;
参考文献
Wu, Fanghui; Li, Hongming; Hong, Ran; Deng, Li
Angewandte Chemie - International Edition, 2006 , vol. 45, # 6 p. 947 - 950
反应条件
sodium hydride in tetrahydrofuran
0.75 h; Heating / reflux;
参考文献
BRANDEIS UNIVERSITY
Patent: WO2005/121137 A1, 2005 ;
Location in patent: Page/Page column 125 ;
反应条件
hydrogenchloride; sodium methylate in water
参考文献
E. I. du Pont de Nemours and Company
Patent: US1705 H1, 1998 ;
反应条件
hydroxylamine hydrochloride; sodium acetate in tetrahydrofuran; water
4 h; Reflux;
参考文献
PATHWAY THERAPEUTICS INC.; BROWN, David, S.; MATTHEWS, David, J.
Patent: WO2012/135166 A1, 2012 ;
Location in patent: Page/Page column 77-78 ;
WO 2012/135166 A1
反应条件
glucose-6-phosphate dehydrogenase; glucose-6-phosphate; 4-hydroxyacetophenone monooxygenase; NADPH
T=20°C; Baeyer-Villiger oxidation; pH=9; 72 h; aq. Tris-HCl bufferEnzymatic reaction;
参考文献
Rioz-Martinez, Ana; De Gonzalo; Torres Pazmino, Daniel E.; Fraaije, Marco W.; Gotor, Vicente
European Journal of Organic Chemistry, 2009 , # 15 p. 2526 - 2532
