5-溴-4-氯-2,6-二甲氧基嘧啶合成路线 （共 2 条）
反应条件
bromine; sodium hydrogencarbonate in methanol; water
T=20°C; 2 h; Product distribution / selectivity;
参考文献
Guo, Hongyan; Kim, Choung U.; Kim, Hae Soo; Lee, Chong-Kyo; Lee, Ill Young; Mitchell, Michael L.; Son, Jong Chan; Xu, Lianhong
Patent: US2008/70920 A1, 2008 ;
Location in patent: Page/Page column 99-100; 109 ;
反应条件
1.1: i-PrMgCl*LiCl / tetrahydrofuran / 0.25 h / 20 °C
1.2: 82 percent / tetrahydrofuran / 4 h / -35 °C
2.1: 91 percent / hydrazine monohydrate / ethanol / 0.5 h / Heating
View Scheme
参考文献
Boudet, Nadege; Knochel, Paul
Organic Letters, 2006 , vol. 8, # 17 p. 3737 - 3740
