2-溴-N-[3-[(1-氧代丁基)氨基]苯基]苯甲酰胺合成路线 （共 3 条）
反应条件
1: 2-Bromobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
3 h; Inert atmosphereCooling with ice;
2: 3-butyrylaminoaniline With pyridine in dichloromethane
18 h; Inert atmosphere;
参考文献
Dockendorff, Chris; Aisiku, Omozuanvbo; Verplank, Lynn; Dilks, James R.; Smith, Daniel A.; Gunnink, Susanna F.; Dowal, Louisa; Negri, Joseph; Palmer, Michelle; MacPherson, Lawrence; Schreiber, Stuart L.; Flaumenhaft, Robert
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 3 p. 232 - 237
反应条件
1.1: 5 Pd(II)/C(eggshell); hydrogen / methanol / 16 h
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Inert atmosphere; Cooling with ice
2.2: 18 h / Inert atmosphere
View Scheme
参考文献
Dockendorff, Chris; Aisiku, Omozuanvbo; Verplank, Lynn; Dilks, James R.; Smith, Daniel A.; Gunnink, Susanna F.; Dowal, Louisa; Negri, Joseph; Palmer, Michelle; MacPherson, Lawrence; Schreiber, Stuart L.; Flaumenhaft, Robert
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 3 p. 232 - 237
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
2.1: 5 Pd(II)/C(eggshell); hydrogen / methanol / 16 h
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Inert atmosphere; Cooling with ice
3.2: 18 h / Inert atmosphere
View Scheme
参考文献
Dockendorff, Chris; Aisiku, Omozuanvbo; Verplank, Lynn; Dilks, James R.; Smith, Daniel A.; Gunnink, Susanna F.; Dowal, Louisa; Negri, Joseph; Palmer, Michelle; MacPherson, Lawrence; Schreiber, Stuart L.; Flaumenhaft, Robert
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 3 p. 232 - 237
