1: 1.) n-BuLi / 1.) Et2O, hexane, -45 deg C, 30 min, 2 a.) -75 deg C, b.) 0 deg C, 10 min 2: 75 percent / NH2OH*HCl, NaOAc / H2O / 0.17 h 3: H2 / Raney Ni / ethanol; H2O / 4.5 h / 2585.7 Torr View Scheme
参考文献
Kruse, Lawrence I.; Kaiser, Carl; DeWolf, Walter E.; Finkelstein, Joseph A.; Frazee, James S.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 781 - 789
1: 56 percent / H2O / 72 h / Heating
2: 95 percent / SOCl2 / CHCl3 / 2 h / Heating
3: 97 percent / dimethylformamide / 1 h / 80 °C
4: 85 percent / aq. NaOH / 1.17 h / Heating
5: 44 percent / ethanol / 4.5 h / Heating
View Scheme
参考文献
Birker, Paul J. M. W. L.; Godefroi, Eric F.; Helder, Janneke; Reedijk, Jan
Journal of the American Chemical Society, 1982 , vol. 104, # 26 p. 7556 - 7560
