2-氨基-3-甲氧基-5-溴吡啶合成路线 （共 14 条）
反应条件
1.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 1.2: 1 h / 20 °C / pH 13 2.1: methanol / 3 h / 75 °C View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/81316 A1, 2011 ;
反应条件
hydrogen bromide; bromine; sodium nitrite in water T=0°C; 1.66667 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; ARONOV, Alex; COME, Jon; COTTRELL, Kevin; GREY, Ronald; LE TIRAN, Amaud; MARONE, Valerie; MARTINEZ-BOTELLA, Gabriel; MESSERSMITH, David; HUCK, Emilie, Porter
Patent: WO2010/135014 A1, 2010 ;
Location in patent: Page/Page column 53-55 ;
WO 2010/135014 A1
反应条件
1.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 1.2: 1 h / 20 °C / pH 13 2.1: methanol / 3 h / 75 °C 3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 9 h / 20 - 40 °C / Inert atmosphere View Scheme
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/81316 A1, 2011 ;
反应条件
potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine in 1,4-dioxane
T=110°C; 6 h; Inert atmosphere;
参考文献
Huang, Zilin; Jin, Jeff; Machajewski, Timothy; Antonios-McCrea, William R.; McKenna, Maureen; Poon, Daniel; Renhowe, Paul A.; Sendzik, Martin; Shafer, Cynthia; Smith, Aaron; Xu, Yongjin; Zhang, Qiong; Chen, Zheng
Patent: US2013/210818 A1, 2013 ;
Location in patent: Paragraph 0382 ;
