3-氰基-6-甲基-2-吡啶酮合成路线 （共 39 条）
反应条件
1: 70 percent / Bu4NBr; P2O5 / toluene / 4 h / Heating
2: 77 percent / DIBAL / CH2Cl2 / -78 °C
View Scheme
参考文献
Chelucci, Giorgio; Addis, Daniele; Baldino, Salvatore
Tetrahedron Letters, 2007 , vol. 48, # 19 p. 3359 - 3362
反应条件
1: 1) lithium diisopropylamide / 1) THF, 0 deg C, 2 h, 2) THF, 0 deg C, 2 h, then r.t. overnight
2: H2SO4, acetic anhydride / Ambient temperature
3: 5.5 g / 20percent NaOH / 40 h / Heating
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参考文献
DeJohn; Domagala; Kaltenbronn; Krolls
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1295 - 1302
反应条件
lithium diisopropyl amide
1) THF, 0 deg C, 2 h, 2) THF, 0 deg C, 2 h, then r.t. overnight; Yield given. Multistep reaction;
参考文献
DeJohn; Domagala; Kaltenbronn; Krolls
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1295 - 1302
反应条件
1: 85 percent / 20percent NaOH / 24 h / 140 °C / pressure vessel
2: 100 percent / dimethylformamide / 2.5 h / 55 °C
View Scheme
参考文献
DeJohn; Domagala; Kaltenbronn; Krolls
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1295 - 1302
反应条件
1: POCl3; chlorobenzene; PCl5
2: ethanolic NH3 / 130 - 150 °C
3: aqueous H3PO4 / 140 °C
View Scheme
参考文献
Lespagnol et al.
Bulletin de la Societe de Pharmacie de Lille, 1955 , p. 60
反应条件
1: 10.5 g / phosphorus oxychloride / 2 h / Heating
2: 43 percent / sodamide / 6 h / 130 °C
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参考文献
Matsukawa; Matsuno
Yakugaku Zasshi, 1944 , vol. 64, # 3 p. 145,150
Chem.Abstr., 1951 , p. 4724
反应条件
1: acetic acid anhydride; urea; fuming HNO3
2: POCl3; PCl5
3: diethyl ether; SnCl2; concentrated aqueous HCl
4: aqueous CuSO4 / Diazotization
View Scheme
参考文献
Perez-Medina et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 2574,2577
反应条件
lithium diisopropyl amide
1) THF, 0 deg C, 2 h, 2) THF, 0 deg C, 2 h, then r.t. overnight; Yield given. Multistep reaction;
参考文献
DeJohn; Domagala; Kaltenbronn; Krolls
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1295 - 1302
反应条件
1: acetic acid anhydride; urea; fuming HNO3
2: POCl3; PCl5
3: diethyl ether; SnCl2; concentrated aqueous HCl
View Scheme
参考文献
Perez-Medina et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 2574,2577
