5,6,7,8-四氢-1-萘甲酸合成路线 （共 37 条）
反应条件
hydrogen; acetic acid; palladium 10 on activated carbon T=80 - 85°C; P=2942.29 - 3677.86 Torr;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; KATKAM, Srinivas; SAGYAM, Rajeshwar Reddy; SUNKARA, Vishnuvardhan; MUNAGALA, Sridhar; MUTTAVARAPU, Murali Mohan
Patent: WO2010/56656 A2, 2010 ;
Location in patent: Page/Page column 20-21 ;
反应条件
hydrogen; palladium on activated charcoal in acetic acid 6 h;
参考文献
Connolly, Terrence J.; Durst, Tony
Tetrahedron, 1997 , vol. 53, # 47 p. 15969 - 15982
反应条件
1: With n-butyllithium in Dry THF; hexane T=-78 - 25°C; 1.16667 h; 2: With hydrogenchloride pH=1;
参考文献
ASTRAZENECA AB
Patent: WO2004/792 A1, 2003 ;
Location in patent: Page 22 ;
反应条件
nickel; sodium carbonate T=75°C; P=128714 Torr; Hydrogenation;
参考文献
Dauben et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 1393,1397
反应条件
hydrogenchloride in water 18 h; Heating;
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
diethyl ether; lithium Behandeln des Reaktionsgemisches mit festem CO2;
参考文献
Fenton et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 979,980
反应条件
hydrogen; palladium in acetic acid
参考文献
Kuhn,R.; Butula,I.
Justus Liebigs Annalen der Chemie, 1968 , vol. 718, p. 50 - 77
反应条件
1: 1) nBuLi, TMEDA / 1) pentane, reflux, 2) pentane 2: hydrogen / Pd/C / acetic acid View Scheme
参考文献
Facey; Connolly; Bensimon; Durst
Canadian Journal of Chemistry, 1996 , vol. 74, # 10 p. 1844 - 1851
反应条件
1: 1) TMEDA, n-BuLi / 1) in dry ether at reflux for 1h 2) CO2 as a continous stream for 1h 2: 1) SOCl2 3: 1) BF3*THF 2) NaOH, H2O2 / 1) for 1h 2) at 50 deg C for 1h 4: 95 percent / triethylamine / CH2Cl2 / -22 °C 5: 94 percent / LiBr / dimethylformamide 6: 84 percent / Mg / tetrahydrofuran 7: 72 percent / 4.5M HCl / H2O / 18 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 65 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 24 h / 90 °C 2: 1) TMEDA, n-BuLi / 1) in dry ether at reflux for 1h 2) CO2 as a continous stream for 1h 3: 1) SOCl2 4: 1) BF3*THF 2) NaOH, H2O2 / 1) for 1h 2) at 50 deg C for 1h 5: 95 percent / triethylamine / CH2Cl2 / -22 °C 6: 94 percent / LiBr / dimethylformamide 7: 84 percent / Mg / tetrahydrofuran 8: 72 percent / 4.5M HCl / H2O / 18 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
