1-甲基-5-氧代-L-脯氨酸甲酯合成路线 （共 5 条）
反应条件
sodium hydride 1.) DMF, rt, 8 h, 2.) 0 deg C, overnight; Yield given. Multistep reaction;
参考文献
AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy; CAI, Zhenwei; CUI, Dawei; ZHOU, Ding
Patent: WO2013/107291 A1, 2013 ;
Location in patent: Page/Page column 75 ;
反应条件
in hexane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Abbott Laboratories
Patent: US5409946 A1, 1995 ;
US 5409946 A
反应条件
1: conc. H2SO4 / benzene / 20 h / Heating 2: 1.) NaH / 1.) benzene, a) room temp., b) 2 h, reflux; 2.) reflux, 24 h View Scheme
参考文献
Beani; Bianchi; Baraldi; Manfredini; Pollini
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 11 p. 1187 - 1191
反应条件
sodium hydride 1.) benzene, a) room temp., b) 2 h, reflux; 2.) reflux, 24 h; Multistep reaction;
参考文献
Beani; Bianchi; Baraldi; Manfredini; Pollini
Arzneimittel-Forschung/Drug Research, 1990 , vol. 40, # 11 p. 1187 - 1191
反应条件
sodium hydroxide; lithium aluminium tetrahydride in tetrahydrofuran; water
参考文献
Merck and Co., Inc.
Patent: US5006511 A1, 1991 ;
US 5006511 A
