反应条件
1: 75 percent / Ph3P, DEAD / tetrahydrofuran / 1 h / 32 °C
2: 91 percent / AIBN, Bu3SnH / benzene / 6 h / Heating
3: 99 percent / 5 M HCl / ethanol / 1.) reflux, 2 h, 2.) RT, 16 h
4: 30 percent / Et3N / CH2Cl2 / 72 h / Ambient temperature
View Scheme
参考文献
Gaster, Laramie M.; Blaney, Frank E.; Davies, Susannah; Duckworth, D. Malcolm; Ham, Peter; Jenkins, Sarah; Jennings, Andrew J.; Joiner, Graham F.; King, Frank D.; Mulholland, Keith R.; Wyman, Paul A.; Hagan, Jim J.; Hatcher, Jon; Jones, Brian J.; Middlemiss, Derek N.; Price, Gary W.; Riley, Graham; Roberts, Claire; Routledge, Carol; Selkirk, Julie; Slade, Paula D.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1218 - 1235