(D,l)-4-氨基-2-甲基-丁酸合成路线 （共 15 条）
反应条件
1: 140 °C 2: quinine 3: N2H4+H2O; ethanol 4: lithium alanate; THF View Scheme
参考文献
Adams; Fles
Journal of the American Chemical Society, 1959 , vol. 81, p. 5803
反应条件
1: 140 °C 2: quinine 3: N2H4+H2O; ethanol 4: lithium alanate; THF View Scheme
参考文献
Adams; Fles
Journal of the American Chemical Society, 1959 , vol. 81, p. 5803
反应条件
titanium(IV) isopropylate in 1,2-dichloro-ethane 21 h; Heating;
参考文献
Mader, Mary; Helquist, Paul
Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3049 - 3052
反应条件
hydrogenchloride; acetic acid
T=140°C; 18 h;
参考文献
Duke, Rujee K.; Chebib, Mary; Hibbs, David E.; Mewett, Kenneth N.; Johnston, Graham A.R.
Tetrahedron Asymmetry, 2004 , vol. 15, # 11 p. 1745 - 1751
反应条件
1.1: 94 percent / p-toluenesulfonic acid / benzene / Heating
2.1: N-bromosuccinimide; dibenzoylperoxide / CCl4 / 18 h / Heating
2.2: dimethylformamide / 18 h / 140 °C
3.1: 98 percent / hydrogen / Pd on C / ethanol / 20 h / 3040 Torr
4.1: 65 percent / hydrochloric acid; acetic acid / 18 h / 140 °C
View Scheme
参考文献
Duke, Rujee K.; Chebib, Mary; Hibbs, David E.; Mewett, Kenneth N.; Johnston, Graham A.R.
Tetrahedron Asymmetry, 2004 , vol. 15, # 11 p. 1745 - 1751
反应条件
1.1: N-bromosuccinimide; dibenzoylperoxide / CCl4 / 18 h / Heating
1.2: dimethylformamide / 18 h / 140 °C
2.1: 98 percent / hydrogen / Pd on C / ethanol / 20 h / 3040 Torr
3.1: 65 percent / hydrochloric acid; acetic acid / 18 h / 140 °C
View Scheme
参考文献
Duke, Rujee K.; Chebib, Mary; Hibbs, David E.; Mewett, Kenneth N.; Johnston, Graham A.R.
Tetrahedron Asymmetry, 2004 , vol. 15, # 11 p. 1745 - 1751
反应条件
1: 98 percent / hydrogen / Pd on C / ethanol / 20 h / 3040 Torr
2: 65 percent / hydrochloric acid; acetic acid / 18 h / 140 °C
View Scheme
参考文献
Duke, Rujee K.; Chebib, Mary; Hibbs, David E.; Mewett, Kenneth N.; Johnston, Graham A.R.
Tetrahedron Asymmetry, 2004 , vol. 15, # 11 p. 1745 - 1751
反应条件
hydrogen; oxygen in water
3 h;
参考文献
Nomoto, Shinya; Harada, Kaoru
Chemistry Letters, 1985 , p. 145 - 148
反应条件
hydrogenchloride
14 h; Heating;
参考文献
Jackson, W. Roy; Perlmutter, Patrick; Smallridge, Andrew J.
Australian Journal of Chemistry, 1988 , vol. 41, # 8 p. 1201 - 1208
反应条件
hydrogen; oxygen in water
3 h;
参考文献
Nomoto, Shinya; Harada, Kaoru
Chemistry Letters, 1985 , p. 145 - 148
