2’-氨基-4’-甲氧基苯乙酮合成路线 （共 20 条）
反应条件
1: With AlCl3, aluminium chloride; boron trichloride in dichloromethane; 1,2-dichloro-ethane T=80°C; Friedel Crafts acylation; 20 h; 2: With hydrogenchloride; water in dichloromethane; 1,2-dichloro-ethane
参考文献
Jin, Guo Hua; Ha, Sang Keun; Park, Hye Min; Kang, Bomi; Kim, Sun Yeou; Kim, Hee-Do; Ryu, Jae-Ha; Jeon, Raok
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4092 - 4094
反应条件
1: 3-methoxy-aniline With boron trichloride in dichloromethane T=-78 - -50°C; 1 h; 2: acetyl chloride With AlCl3, aluminium chloride in dichloromethane T=-50 - 20°C; 3: With sodium hydroxide in dichloromethane; water pH=7;
参考文献
TAIGEN BIOTECHNOLOGY CO. LTD.
Patent: WO2008/95058 A1, 2008 ;
Location in patent: Page/Page column 47 ;
反应条件
iron; acetic acid in ethanol 1 h;
参考文献
NOVARTIS VACCINES and DIAGNOSTICS, INC.
Patent: WO2007/117607 A2, 2007 ;
Location in patent: Page/Page column 345 ;
反应条件
1: 4-isopropylthiazole-2-carbonyl chloride With boron trichloride in dichloromethane; toluene T=0 - 5°C; 1.16667 h; 2: acetonitrile in dichloromethane; toluene T=0°C; 1 h; 3: With AlCl3, aluminium chloride; water more than 3 stages;
参考文献
IDENIX PHARMACEUTICALS, INC.
Patent: WO2009/14730 A1, 2009 ;
Location in patent: Page/Page column 118 ;
WO 2009/014730 A1
反应条件
1: 3-methoxy-aniline With boron trichloride in dichloromethane T=-50°C; 0.833333 h; 2: acetyl chloride With AlCl3, aluminium chloride T=-50 - 40°C;
参考文献
MEDIVIR AB
Patent: WO2005/73195 A2, 2005 ;
Location in patent: Page/Page column 117-118 ;
WO 2005/073195 A2
反应条件
sodium hydroxide; BCl3; acetyl chloride; AlCl3 in dichloromethane
参考文献
Heinicke, Grant; Hung, Tran V.; Prager, Rolf H.; Ward, A. David
Australian Journal of Chemistry, 1984 , vol. 37, # 4 p. 831 - 844
反应条件
sodium hydroxide in water; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; isopropyl alcohol; toluene
参考文献
Idenix Pharmaceuticals, Inc.
Patent: US2010/260710 A1, 2010 ;
反应条件
aluminium trichloride; boron trichloride in dichloromethane; toluene T=52°C; Sugasawa acylation;
参考文献
Frutos, Rogelio P.; Haddad, Nizar; Houpis, Ioannis N.; Johnson, Michael; Smith-Keenan, Lana L.; Fuchs, Victor; Yee, Nathan K.; Farina, Vittorio; Faucher, Anne-Marie; Brochu, Christian; Hache, Bruno; Duceppe, Jean-Simon; Beaulieu, Pierre
Synthesis, 2006 , # 15 p. 2563 - 2567
反应条件
in ethylene glycol dimethyl ether; ethylene glycol diethyl ether T=0°C; 2 h; Inert atmosphere;
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 6 p. 1444 - 1447
反应条件
1: With sulfuric acid T=0 - 20°C; 2 h; Inert atmosphereSchlenk technique; 2: With sodium hydrogencarbonate Inert atmosphereSchlenk technique;
参考文献
Bhanuchandra; Ramu Yadav; Rit, Raja K.; Rao Kuram, Malleswara; Sahoo, Akhila K.
Chemical Communications, 2013 , vol. 49, # 45 p. 5225 - 5227
