2’-氨基-4’-甲氧基苯乙酮合成路线 （共 20 条）
反应条件
tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane T=100°C; 24 h; Inert atmosphere;
参考文献
Huang, Jinkun; Chen, Ying; King, Anthony O.; Dilmeghani, Mina; Larsen, Robert D.; Faul, Margaret M.
Organic Letters, 2008 , vol. 10, # 12 p. 2609 - 2612
反应条件
PPA; Polyphosphoric acid (PPA) T=110 - 115°C; 1.5 h;
参考文献
Heinicke, Grant; Hung, Tran V.; Prager, Rolf H.; Ward, A. David
Australian Journal of Chemistry, 1984 , vol. 37, # 4 p. 831 - 844
反应条件
PPA; Polyphosphoric acid (PPA) T=110 - 115°C; 1.5 h;
参考文献
Heinicke, Grant; Hung, Tran V.; Prager, Rolf H.; Ward, A. David
Australian Journal of Chemistry, 1984 , vol. 37, # 4 p. 831 - 844
反应条件
1: 50 percent / ethyl polyphosphate (ppe) / 1.5 h / 100 - 105 °C 2: 35 percent / polyphosphoric acid (ppa) / 1.5 h / 110 - 115 °C View Scheme
参考文献
Heinicke, Grant; Hung, Tran V.; Prager, Rolf H.; Ward, A. David
Australian Journal of Chemistry, 1984 , vol. 37, # 4 p. 831 - 844
反应条件
PPA; Polyphosphoric acid (PPA) T=80°C; 2 h;
参考文献
Heinicke, Grant; Hung, Tran V.; Prager, Rolf H.; Ward, A. David
Australian Journal of Chemistry, 1984 , vol. 37, # 4 p. 831 - 844
反应条件
1: ethoxymagnesio-malonic acid diethyl ester; diethyl ether / anschl. mit Essigsaeure und wss. H2SO4 2: iron-powder; aqueous acetic acid View Scheme
参考文献
Osborn; Schofield
Journal of the Chemical Society, 1955 , p. 2100,2102
反应条件
1: C2H5ONa / ethanol / 1 h / Heating 2: aq. HCl View Scheme
参考文献
Coltman, Stephen C. W.; Eyley, Stephen C.; Raphael, Richard A.
Synthesis, 1984 , # 2 p. 150 - 152
反应条件
1: 63 percent / AlCl3 / CH2Cl2 / 22 h / Ambient temperature
2: 87 percent / K2CO3 / acetone / 18 h / Heating
3: 54 percent / 1 h / 200 °C
4: 100 percent / H2 / 5percent Pd/C / ethanol / 1 h / 1551.4 Torr
View Scheme
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826
反应条件
aluminium trichloride in dichloromethane
22 h; Ambient temperature;
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 6 h / 0 - 20 °C
2: ammonium acetate / dimethyl sulfoxide / 20 h / 20 °C
3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 6 h / 80 °C
View Scheme
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
