(E)-2-氰基-3-乙氧基丙烯酸乙酯合成路线 （共 38 条）
参考文献
Schmidt; Druey
Helvetica Chimica Acta, 1956 , vol. 39, p. 986,988
反应条件
in ethanol 12 h; Heating;
参考文献
Kopp; Lancelot; Dallemagne; Rault
Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1045 - 1050
反应条件
Montmorillonite K10 in isopropyl alcohol Heating;
参考文献
Jagath Reddy; Sailaja; Manjula; Srinivasa Rao; Khalilullah; Latha
Heterocyclic Communications, 2005 , vol. 11, # 5 p. 385 - 388
反应条件
sodium acetate in water; acetic acid T=100°C; 15 h; Inert atmosphere;
参考文献
Sutherland, Hamish S.; Blaser, Adrian; Kmentova, Iveta; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Palmer, Brian D.; Denny, William A.; Thompson, Andrew M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 2 p. 855 - 866
参考文献
Schmidt et al.
Helvetica Chimica Acta, 1958 , vol. 41, p. 1052,1056
Helvetica Chimica Acta, 1959 , vol. 42, p. 349,354
反应条件
1: 3-Nitrophenylhydrazine hydrochloride With sodium hydroxide in ethanol 0.5 h; 2: E-2-cyano-3-ethoxyacrylic acid ethyl ether in ethanol T=80°C; 2 h;
参考文献
IRM LLC
Patent: WO2007/120454 A1, 2007 ;
Location in patent: Page/Page column 63 ;
WO 2007/120454 A1
反应条件
potassium carbonate in ethanol 20 h; Reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.
Patent: WO2013/22818 A1, 2013 ;
Location in patent: Paragraph 00321 ;
WO 2013/022818 A1
反应条件
Montmorillonite K10 in isopropyl alcohol Heating;
参考文献
Jagath Reddy; Sailaja; Manjula; Srinivasa Rao; Khalilullah; Latha
Heterocyclic Communications, 2005 , vol. 11, # 5 p. 385 - 388
反应条件
1: in benzene 1 h; Heating / reflux; 2: With hydrogenchloride; ethanol; water T=80°C;
参考文献
Cephalon, Inc.
Patent: US2007/281949 A1, 2007 ;
Location in patent: Page/Page column 89 ;
反应条件
1: benzene 2: water; ethanol; HCl View Scheme
参考文献
Schmidt et al.
Helvetica Chimica Acta, 1959 , vol. 42, p. 349,358
