1,2-二氟-4-(甲磺酰基)苯合成路线 （共 4 条）
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=20°C;
参考文献
WO2007/31747 A1, ;
Page/Page column 59-60 ;
WO 2007/031747 A1
反应条件
1: methanesulfonic acid With thionyl chloride Reflux; 2: ortho-difluorobenzene With trifluorormethanesulfonic acid T=80 - 120°C;
参考文献
US2009/286812 A1, ;
Page/Page column 18 ;
反应条件
AlCl3, aluminium chloride T=90°C; 18 h;
参考文献
US2004/220194 A1, ;
Page 23 ;
US 20040220194 A1
反应条件
sodium carbonate in N,N-dimethyl-formamide
T=60°C; 18 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; DYCK, Brian; TRAN, Joe A.; TAMIYA, Junko; JOVIC, Florence; VICKERS, Troy; CHEN, Chen; HARRIOTT, Nicole; COON, Timothy; ASHWEEK, Neil J.
Patent: WO2010/149684 A1, 2010 ;
Location in patent: Page/Page column 56 ;
WO 2010/149684 A1
