乙基6-氧代-6-苯基己烷酸酯合成路线 （共 14 条）
反应条件
tris(4-methoxyphenyl)-phosphine; water; dicarbonic acid,dimethyl ester; palladium diacetate in tetrahydrofuran T=20°C;
参考文献
Goossen, Lukas J.; Winkel, Lars; Doehring, Arno; Ghosh, Keya; Paetzold, Jens
Synlett, 2002 , # 8 p. 1237 - 1240
反应条件
1: 5-Iodo-pentanoic acid ethyl ester With chloro-trimethyl-silane; ethylene dibromide; zinc in tetrahydrofuran T=55 - 60°C; 0.5 h; 2: PhCOSEt With 10percent Pd(OH)2/C in tetrahydrofuran; N,N-dimethyl-formamide; toluene T=25°C; Fukuyama coupling; 71 h; Further stages.;
参考文献
Mori, Yoshikazu; Seki, Masahiko
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1571 - 1574
反应条件
sulfuric acid T=20°C;
参考文献
Guijarro, David; Pablo, Oscar; Yus, Miguel
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 3647 - 3654
反应条件
cerium(IV) sulphate; iodine T=65°C; Oxidation; esterification, ring cleavage; 18 h;
参考文献
He, Liangyou; Kanamori, Miyuki; Horiuchi, C. Akira
Journal of Chemical Research - Part S, 1999 , # 2 p. 122 - 123
反应条件
1: 5-Iodo-pentanoic acid ethyl ester With chloro-trimethyl-silane; zinc; 1,1-dibromomethane in tetrahydrofuran T=20 - 60°C; 16 h; 2: With lithium chloride in tetrahydrofuran T=0°C; 0.166667 h; 3: benzoyl chloride in tetrahydrofuran T=0°C; 3 h; Further stages.;
参考文献
Woo, Soon Hyung; Frechette, Sylvie; Khalil, Elie Abou; Bouchain, Giliane; Vaisburg, Arkadii; Bernstein, Naomy; Moradei, Oscar; Leit, Silvana; Allan, Martin; Fournel, Marielle; Trachy-Bourget, Marie-Claude; Li, Zuomei; Besterman, Jeffrey M.; Delorme, Daniel
Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2877 - 2885
反应条件
diethylzinc in dichloromethane T=20°C; 2 h; Title compound not separated from byproducts.;
参考文献
Li, Lezhen; Cai, Peijie; Guo, Qingxiang; Xue, Song
Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3516 - 3522
反应条件
aluminium trichloride; benzene
参考文献
Raper; Wayne
Biochemical Journal, 1928 , vol. 22, p. 193
反应条件
vanadium(III) chloride 1.) dichloromethane, -78 grad C, 20 min, 2.) dichloromethane, -78 grad C, 1.5 h, room temp. 16 h; Yield given. Multistep reaction;
参考文献
Hirao, Toshikazu; Misu, Daisuke; Yao, Koichi; Agawa, Toshio
Tetrahedron Letters, 1986 , vol. 27, # 8 p. 929 - 932
反应条件
1: aluminium chloride 2: sodium amide; toluene 3: sodium amide; toluene 4: permanganate 5: hydrogen chloride View Scheme
参考文献
Bauer
Annales de Chimie (Cachan, France), 1914 , vol. <9> 1, p. 408
反应条件
1: permanganate 2: hydrogen chloride View Scheme
参考文献
Bauer
Annales de Chimie (Cachan, France), 1914 , vol. <9> 1, p. 408
