7-氟-1H-吲哚-5-甲醛合成路线 （共 5 条）
反应条件
pyridinium chlorochromate in dichloromethane
T=0°C; 2 h;
参考文献
Wang, Le; Woods, Keith W.; Li, Qun; Barr, Kenneth J.; McCroskey, Richard W.; Hannick, Steven M.; Gherke, Laura; Credo, R. Bruce; Hui, Yu-Hua; Marsh, Kennan; Warner, Robert; Lee, Jang Y.; Zielinski-Mozng, Nicolette; Frost, David; Rosenberg, Saul H.; Sham, Hing L.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1697 - 1711
反应条件
1: 98 percent / Et3N / CH2Cl2 / 3 h / 20 °C
2: 29 percent / tetrahydrofuran / 2 h / -40 °C
3: 84 percent / Pd(dppf)Cl2; Et3N / 20 h / 120 °C / 23272.3 Torr
4: 89 percent / DIBAL / toluene / 2 h / -78 °C
5: 81 percent / PCC / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Wang, Le; Woods, Keith W.; Li, Qun; Barr, Kenneth J.; McCroskey, Richard W.; Hannick, Steven M.; Gherke, Laura; Credo, R. Bruce; Hui, Yu-Hua; Marsh, Kennan; Warner, Robert; Lee, Jang Y.; Zielinski-Mozng, Nicolette; Frost, David; Rosenberg, Saul H.; Sham, Hing L.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1697 - 1711
反应条件
1: 89 percent / DIBAL / toluene / 2 h / -78 °C
2: 81 percent / PCC / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Wang, Le; Woods, Keith W.; Li, Qun; Barr, Kenneth J.; McCroskey, Richard W.; Hannick, Steven M.; Gherke, Laura; Credo, R. Bruce; Hui, Yu-Hua; Marsh, Kennan; Warner, Robert; Lee, Jang Y.; Zielinski-Mozng, Nicolette; Frost, David; Rosenberg, Saul H.; Sham, Hing L.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1697 - 1711
反应条件
1: 29 percent / tetrahydrofuran / 2 h / -40 °C
2: 84 percent / Pd(dppf)Cl2; Et3N / 20 h / 120 °C / 23272.3 Torr
3: 89 percent / DIBAL / toluene / 2 h / -78 °C
4: 81 percent / PCC / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Wang, Le; Woods, Keith W.; Li, Qun; Barr, Kenneth J.; McCroskey, Richard W.; Hannick, Steven M.; Gherke, Laura; Credo, R. Bruce; Hui, Yu-Hua; Marsh, Kennan; Warner, Robert; Lee, Jang Y.; Zielinski-Mozng, Nicolette; Frost, David; Rosenberg, Saul H.; Sham, Hing L.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1697 - 1711
反应条件
1: 84 percent / Pd(dppf)Cl2; Et3N / 20 h / 120 °C / 23272.3 Torr
2: 89 percent / DIBAL / toluene / 2 h / -78 °C
3: 81 percent / PCC / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Wang, Le; Woods, Keith W.; Li, Qun; Barr, Kenneth J.; McCroskey, Richard W.; Hannick, Steven M.; Gherke, Laura; Credo, R. Bruce; Hui, Yu-Hua; Marsh, Kennan; Warner, Robert; Lee, Jang Y.; Zielinski-Mozng, Nicolette; Frost, David; Rosenberg, Saul H.; Sham, Hing L.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 8 p. 1697 - 1711
