3-氨基-3-甲基丁-1-醇合成路线 （共 14 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=3677.86 Torr; 6 h;
参考文献
Cociorva, Oana; Li, Bei; Szardenings, Katrin; Fukuda, Yasumichi; Nomura, Masahiro; Seto, Shigeki; Yumoto, Kazuhiro; Okada, Kyoko; Nakamura, Ayako
Patent: US2007/254866 A1, 2007 ;
Location in patent: Page/Page column 102 ;
反应条件
sodium hydroxide T=80°C; 18 h;
参考文献
Jessen, Claus U.; Selvig, Helle; Valsborg, Jacob S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, # 4 p. 265 - 275
反应条件
1: With boron trifluoride diethyl etherate in tetrahydrofuran 3.5 h; RefluxInert atmosphere; 2: With dimethylsulfide borane complex in methanethiol 6 h; RefluxInert atmosphere; 3: With sodium hydroxide in tetrahydrofuran; water 15 h; Inert atmosphereReflux;
参考文献
Hansen, Camilla P.; Jensen, Anders A.; Christensen, Jeppe K.; Balle, Thomas; Liljefors, Tommy; Frolund, Bente
Journal of Medicinal Chemistry, 2008 , vol. 51, # 23 p. 7380 - 7395
反应条件
hydrogenchloride in methanol T=24°C; 12 h;
参考文献
Gassman, Paul G.; Haberman, Leonard M.
Tetrahedron Letters, 1985 , vol. 26, # 41 p. 4971 - 4974
反应条件
1: With sulfuric acid; 2-hydroxy-2-methyl-propionitrile in hexane 2 h; Heating; 2: Alkaline hydrolysis;
参考文献
Kuznetsov; Brusilovskii
Chemistry of Heterocyclic Compounds, 2001 , vol. 37, # 5 p. 574 - 575
反应条件
lithium aluminium tetrahydride in diethyl ether T=0 - 25°C; 16 h;
参考文献
Low, Eddy; Kim, Bum; Francavilla, Charles; Shiau, Timothy P.; Turtle, Eric D.; O'Mahony, Donogh J.R.; Alvarez, Nichole; Houchin, Ashley; Xu, Ping; Zuck, Meghan; Celeri, Chris; Anderson, Mark B.; Najafi, Ramin; Jain, Rakesh K.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3682 - 3685
反应条件
1: 54 percent / conc. H2SO4 / dibutyl ether / 17 h / Ambient temperature 2: 50percent aq. KOH / 24 h / Heating View Scheme
参考文献
Gassman, Paul G.; Haberman, Leonard M.
Tetrahedron Letters, 1985 , vol. 26, # 41 p. 4971 - 4974
反应条件
potassium hydroxide 8 h; Heating;
参考文献
Pavel', T. M.
Journal of Organic Chemistry USSR (English Translation), 1982 , p. 157 - 159
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 1 p. 178 - 181
反应条件
1: 42 percent / 28-30percent NH3 / H2O / 16 h / 150 °C / 36200.4 Torr 2: 86 percent / LiAlH4 / tetrahydrofuran / 1.) 5 h, reflux, 2.) 36 h, r.t. View Scheme
参考文献
Low, Eddy; Kim, Bum; Francavilla, Charles; Shiau, Timothy P.; Turtle, Eric D.; O'Mahony, Donogh J.R.; Alvarez, Nichole; Houchin, Ashley; Xu, Ping; Zuck, Meghan; Celeri, Chris; Anderson, Mark B.; Najafi, Ramin; Jain, Rakesh K.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3682 - 3685
反应条件
ammonia; water T=80°C;
参考文献
United Gas Improv.Co.
Patent: US2393483 , 1944 ;
