2,2',4'-三氯苯乙酮合成路线 （共 34 条）
反应条件
in para-xylene
T=200°C; 1 h; Microwave irradiation;
参考文献
Obermayer, David; Gutmann, Bernhard; Oliver Kappe
Angewandte Chemie - International Edition, 2009 , vol. 48, # 44 p. 8321 - 8324
反应条件
1: 1) NaH / 1) DMF, 0 deg C, 15 min, 2) MeOH, 0 deg C, 30 min
2: conc.H2SO4 / methanol / Ambient temperature
3: 72 percent / MeONa / methanol / 0.5 h / Heating
4: 30 percent / TsOH / benzene / 3.5 h / Heating
5: 53 percent / n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C
6: 82 percent / dimethylformamide / 4 h / 100 °C
7: 93 percent / 2 N HCl / acetone / 2 h / 60 °C / via hydrochloride
8: 23 mg / MCPBA / CH2Cl2 / 0.17 h / 0 °C
View Scheme
参考文献
Konosu; Takeda; Tajima; Yasuda; Oida
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 5 p. 1258 - 1265
反应条件
in para-xylene
0.333333 h; Heating; Product distribution; Further Variations:Temperatures;
参考文献
Herrero, M. Antonia; Kremsner, Jennifer M.; Kappe, C. Oliver
Journal of Organic Chemistry, 2008 , vol. 73, # 1 p. 36 - 47
参考文献
Koziara, Anna; Mloykowska, Barbara; Majewski, Piotr; Sledzinski, Bogdan; Zwierzak, Andrzej
Polish Journal of Chemistry, 1981 , vol. 55, # 2 p. 399 - 409
