2-(3-硝基苯基)吡啶合成路线 （共 11 条）
反应条件
1: 30percent aq. H2O2 / acetic acid / 20 h / 80 °C 2: 1.) Me2SO4 / 1.) 80-90 deg C, 2 h, 2.) dioxane, H2O, RT, 30 min 3: 5 M aq. HCl / 11 h / Heating View Scheme
参考文献
Honma; Oda; Hashiyama; Hanamoto; Nakai; Inoue; Ishida; Takeda; Ono; Tsuzurahara
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1499 - 1504
反应条件
palladium in ethanol; ethyl acetate; Petroleum ether
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in tetrahydrofuran; ethanol
Suzuki coupling; 65 h; Reflux;
参考文献
UTI LIMITED PARTNERSHIP; BERLINGUETTE, Curtis; BOMBEN, Paolo
Patent: WO2012/155247 A1, 2012 ;
Location in patent: Page/Page column 60 ;
反应条件
nitronium tetrafluoroborate; oxygen; copper diacetate in 1,2,3-trichloro propane
T=130°C; 24 h;
参考文献
Zhang, Lin; Liu, Zhenhua; Li, Huiqin; Fang, Guichun; Barry, Badru-Deen; Belay, Tuemay Abadi; Bi, Xihe; Liu, Qun
Organic Letters, 2011 , vol. 13, # 24 p. 6536 - 6539
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(I) thiophene-2-carboxylate in water
T=50°C; 72 h;
参考文献
Koley, Moumita; Wimmer, Laurin; Schnuerch, Michael; Mihovilovic, Marko D.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1368 - 1373
参考文献
Cell Pathways, Inc.
Patent: US6211220 B1, 2001 ;
反应条件
FeCl3·6H2O; acetic acid; 1,4,7,10-tetraaza-cyclododecane
T=110°C; Suzuki-Miyaura reaction; 12 h; regioselective reaction;
参考文献
Wen, Jun; Qin, Song; Ma, Li-Fang; Dong, Liang; Zhang, Ji; Liu, Shan-Shan; Duan, Yi-Shu; Chen, Shan-Yong; Hu, Chang-Wei; Yu, Xiao-Qi
Organic Letters, 2010 , vol. 12, # 12 p. 2694 - 2697
反应条件
(Dipp2N2C4H6)Pd(η3-cinnamyl)Cl; tetrabutylammomium bromide; sodium hydrogencarbonate in water
Suzuki-Miyaura Coupling; 1 h; Reflux; Catalytic behavior;
参考文献
Kolychev, Eugene L.; Asachenko, Andrey F.; Dzhevakov, Pavel B.; Bush, Alexander A.; Shuntikov, Viacheslav V.; Khrustalev, Victor N.; Nechaev, Mikhail S.
Dalton Transactions, 2013 , vol. 42, # 19 p. 6859 - 6866
参考文献
Kalyani, Dipannita; Sanford, Melanie S.
Organic Letters, 2005 , vol. 7, # 19 p. 4149 - 4152
参考文献
Haworth et al.
Journal of the Chemical Society, 1940 , p. 349,352
