4,6-二氨基-2-溴烟腈合成路线 （共 9 条）
反应条件
hydrogen bromide in water; toluene
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
反应条件
hydrogen bromide in water
参考文献
Warner-Lambert Company
Patent: US6150359 A1, 2000 ;
US 6150359 A
反应条件
hydrogen bromide; acetic acid
参考文献
Durmus, Asuman; Gunbas, Gorkem; Farmer, Steven C.; Olmstead, Marilyn M.; Mascal, Mark; Legese, Belete; Cho, Jae-Young; Beingessner, Rachel L.; Yamazaki, Takeshi; Fenniri, Hicham
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11421 - 11426
反应条件
sodium hydroxide; hydrogen; Pd-BaSO4 in methanol
P=2250.2 Torr; 2 h;
参考文献
Metzger, Roland; Oberdoerfer, Juergen; Schwager, Carlos; Thielecke, Wilfried; Boldt, Peter
Liebigs Annalen der Chemie, 1980 , # 6 p. 946 - 953
反应条件
potassium acetate; palladium monocarbide in tetrahydrofuran; hydrogenchloride
参考文献
Warner-Lambert Company
Patent: US6150359 A1, 2000 ;
US 6150359 A
反应条件
1: 80 percent / NaOH, H2 / 5percent Pd/BaSO4 / methanol / 2 h / 2250.2 Torr
2: 60 percent / 10percent ethanolic NaOH / 5 h / Heating
View Scheme
参考文献
Metzger, Roland; Oberdoerfer, Juergen; Schwager, Carlos; Thielecke, Wilfried; Boldt, Peter
Liebigs Annalen der Chemie, 1980 , # 6 p. 946 - 953
反应条件
T=140°C; 0.166667 h;
参考文献
Junek, Hans; Uray, Georg; Kotzent, Anna
Monatshefte fuer Chemie, 1983 , vol. 114, p. 973 - 982
反应条件
1: methanol With sodium
2: 2-bromo-3-cyano-4,6-diamino-pyridine T=150°C; 0.166667 h; Microwave irradiationSealed tube;
参考文献
Liu, Gang; Sham, Hing L.; Szczepankiewicz, Bruce G.; Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Liu, Bo; Liu, Mei
Patent: US2006/173050 A1, 2006 ;
Location in patent: Page/Page column 40 ;
US 20060173050 A1
反应条件
sodium
24 h; Heating;
参考文献
Junek, Hans; Uray, Georg; Kotzent, Anna
Monatshefte fuer Chemie, 1983 , vol. 114, p. 973 - 982
