3-(三氟甲基)咪唑并[1,2-b][1,2,4]三嗪合成路线 （共 2 条）
反应条件
1: 2-bromoacetaldehyde diethyl acetal With hydrogen bromide
2 h; Heating;
2: 3-amino-5-trifluoromethyl-1,2,4-triazine in ethanol; water
T=60 - 80°C; 43 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2003/93273 A1, 2003 ;
Location in patent: Page/Page column 32-33 ;
WO 03/093273 A1
反应条件
bromine; sodium acetate; acetic acid
T=20°C; 6 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2003/93273 A1, 2003 ;
Location in patent: Page/Page column 33 ;
WO 03/093273 A1
