2-(3-氨基-1,2,4-噻嗪-5-基)-2-丙醇合成路线 （共 8 条）
反应条件
potassium acetate in water
T=90°C; 4 h; Title compound not separated from byproducts;
参考文献
Gauthier Jr., Donald R.; Limanto, John; Devine, Paul N.; Desmond, Richard A.; Szumigala Jr., Ronald H.; Foster, Bruce S.; Volante
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5938 - 5945
反应条件
methanol; acetic acid
T=67°C; 14 h;
参考文献
Gauthier Jr., Donald R.; Limanto, John; Devine, Paul N.; Desmond, Richard A.; Szumigala Jr., Ronald H.; Foster, Bruce S.; Volante
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5938 - 5945
反应条件
acetic acid in methanol
T=67°C; 14 h;
参考文献
Limanto, John; Desmond, Richard A.; Gauthier Jr., Donald R.; Devine, Paul N.; Reamer, Robert A.; Volante
Organic Letters, 2003 , vol. 5, # 13 p. 2271 - 2274
反应条件
1: 1,1-dibromo-3-hydroxy-3-methyl-butan-2-one With potassium acetate
T=95°C; 4 h;
2: aminoguanidine hydrogen carbonate T=23°C; 24 h;
参考文献
Gauthier Jr., Donald R.; Limanto, John; Devine, Paul N.; Desmond, Richard A.; Szumigala Jr., Ronald H.; Foster, Bruce S.; Volante
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5938 - 5945
反应条件
1: tetrahydrofuran / 22 h / 67 °C
2: 32.6 g / acetic acid / methanol / 14 h / 67 °C
View Scheme
参考文献
Limanto, John; Desmond, Richard A.; Gauthier Jr., Donald R.; Devine, Paul N.; Reamer, Robert A.; Volante
Organic Letters, 2003 , vol. 5, # 13 p. 2271 - 2274
反应条件
1.1: 95 percent / Br2 / methanol / 24 h / 23 °C
2.1: KOAc / 4 h / 95 °C
2.2: 28 percent / 24 h / 23 °C
View Scheme
参考文献
Gauthier Jr., Donald R.; Limanto, John; Devine, Paul N.; Desmond, Richard A.; Szumigala Jr., Ronald H.; Foster, Bruce S.; Volante
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5938 - 5945
反应条件
1: 2-bromoacetaldehyde diethyl acetal With hydrogen bromide in water
0.666667 h; Heating / reflux;
2: 2-(3-amino-1,2,4-triazin-5-yl)propan-2-ol With 2-(3-amino-[1,2,4]triazin-6-yl)propan-2-ol in ethanol; water
6 h; Heating / reflux;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2003/93273 A1, 2003 ;
Location in patent: Page/Page column 37-38 ;
WO 03/093273 A1
反应条件
1: 2-bromoacetaldehyde diethyl acetal With water; hydrogen bromide
0.666667 h; Heating / reflux;
2: 2-(3-amino-1,2,4-triazin-5-yl)propan-2-ol; 2-(3-amino-[1,2,4]triazin-6-yl)propan-2-ol 6 h; Heating / reflux;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2003/93272 A1, 2003 ;
Location in patent: Page/Page column 33-34 ;
WO 03/093272 A1
