(S)-(+)-1,2-丙二醇合成路线 （共 56 条）
反应条件
potassium carbonate; triphenylphosphine in tetrachloromethane 24 h; Heatingvar. cyclodehydr. reag., var. solv., var. temp.; regioselectivity; Product distribution;
参考文献
Robinson, Philip L.; Barry, Carey N.; Bass, S. Woody; Jarvis, Susan E.; Evans, Slayton A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5396 - 5398
反应条件
p-toluenesulfonic acid monohydrate in hexane; toluene
参考文献
AGFA-GEVAERT
Patent: US2003/55130 A1, 2003 ;
反应条件
1H-imidazole in N,N-dimethyl-formamide T=25°C; 18 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; GLUNZ, Peter W.; PRIESTLEY, Eldon Scott; JOHNSON, James, A.; WURTZ, Nicholas, Ronald; LADZIATA, Vladimir
Patent: WO2013/184734 A1, 2013 ;
Location in patent: Paragraph 00355; 00356 ;
反应条件
1: (S)-(+)-propylene glycol With trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 0.25 h; Inert atmosphere; 2: 8-nitro-2-(4-oxopiperidin-1-yl)-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one in dichloromethane 0.333333 h; Inert atmosphere;
参考文献
Karoli, Tomislav; Becker, Bernd; Zuegg, Johannes; Moellmann, Ute; Ramu, Soumya; Huang, Johnny X.; Cooper, Matthew A.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7940 - 7944
反应条件
hydrogen bromide
T=0 - 60°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Selvig; Ruud Christensen; Aasen
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1514 - 1518
反应条件
chloroform
d-propylene glycol dibutyrate;
参考文献
Abderhalden; Eichwald
Chemische Berichte, 1918 , vol. 51, p. 1318
