1,2-双(4-氯苯基)-2-羟基乙酮合成路线 （共 62 条）
反应条件
potassium phosphate buffer; thiamine diphosphate; magnesium sulfate; benzaldehyde lyase from Pseudomonas fluorescens in dimethyl sulfoxide T=20°C; pH=7.0; Enzymatic reaction;
参考文献
Demir, Ayhan S.; Ayhan, Peruze; Igdir, A. Cigdem; Duygu, A. Nese
Tetrahedron, 2004 , vol. 60, # 31 p. 6509 - 6512
反应条件
1: 99 percent / aq. NaOH / dimethylsulfoxide 2: 100 percent / n-Bu4NCN / tetrahydrofuran / 1.5 h / Ambient temperature View Scheme
参考文献
Miyashita, Akira; Suzuki, Yumiko; Okumura, Yoko; Iwamoto, Ken-Ichi; Higashino, Takeo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 6 - 11
反应条件
1: 66 percent / DBU / dimethylformamide 2: 98 percent / KCN / dimethylformamide / 0.25 h / 80 °C View Scheme
参考文献
Miyashita; Suzuki; Okumura; Higashino
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 252 - 254
反应条件
trifluorormethanesulfonic acid in dichloromethane T=20°C; stereospecific reaction;
参考文献
Kothapalli, Raveendra Babu; Niddana, Ramana; Balamurugan, Rengarajan
Organic Letters, 2014 , vol. 16, # 5 p. 1278 - 1281
反应条件
5 ruthenium on carbon; oxygen in water T=75°C; 24 h;
参考文献
Akkilagunta, Vijay Kumar; Reddy, Vutukuri Prakash; Kakulapati, Rama Rao
Synlett, 2010 , # 17 p. 2571 - 2574
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene; oxygen / N,N-dimethyl-formamide; ethyl acetate / 6 h / 70 °C 2: N,N-dimethyl-formamide; ethyl acetate / 1.5 h / 20 °C View Scheme
参考文献
Lin, Yang; Lei, Xiaoli; Yang, Qin; Yuan, Jiangjun; Ding, Qiuping; Xu, Jingshi; Peng, Yiyuan
Synthesis (Germany), 2012 , vol. 44, # 17 p. 2699 - 2706
反应条件
1: 50 percent / DBU / dimethylformamide / 0.5 h / 60 °C 2: potassium cyanide / dimethylformamide / 0.5 h / Ambient temperature View Scheme
参考文献
Miyashita; Suzuki; Okumura; Higashino
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 252 - 254
反应条件
sodium methylate in methanol T=30°C; enthalpy-entropy relationship, ΔH(excit.), ΔS(excit.); KineticsThermodynamic data;
参考文献
Morozov, A. A.
Russian Journal of Physical Chemistry, 1986 , vol. 60, # 9 p. 1292 - 1295
Zhurnal Fizicheskoi Khimii, 1986 , vol. 60, p. 2153 - 2158
反应条件
1,3-dimethyl-1H-benzo[d]imidazol-3-ium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
2 h; Heating;
参考文献
Miyashita; Suzuki; Iwamoto; Higashino
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 12 p. 2633 - 2635
反应条件
sodium hydrogen selenide; acetic acid in tetrahydrofuran; ethanol
0.5 h; Ambient temperature;
参考文献
Qiu; Chen; Zhang; Zhou
Synthetic Communications, 1992 , vol. 22, # 11 p. 1529 - 1534
