1,2-双(4-氯苯基)-2-羟基乙酮合成路线 （共 62 条）
反应条件
1: With formic acid
T=85°C; 0.166667 h;
2: With sodium hydrogen sulphate
T=185°C; 3 h;
参考文献
Streciwilk, Wojciech; Cassidy, Jennifer; Hackenberg, Frauke; Mueller-Bunz, Helge; Paradisi, Francesca; Tacke, Matthias
Journal of Organometallic Chemistry, 2014 , vol. 749, p. 88 - 99
反应条件
formaldehyd
T=200 - 220°C;
参考文献
Plummer, Christopher W.; Finke, Paul E.; Mills, Sander G.; Wang, Junying; Tong, Xinchun; Doss, George A.; Fong, Tung M.; Lao, Julie Z.; Schaeffer, Marie-Therese; Chen, Jing; Shen, Chun-Pyn; Stribling, D. Sloan; Shearman, Lauren P.; Strack, Alison M.; Van Der Ploeg, Lex H.T.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1441 - 1446
反应条件
1: SOCl2
2: ethanol / 6 h / Heating
3: piperidine / ethanol / 1 h / Heating
View Scheme
参考文献
Dash; Patra; Mahapatra
Journal of the Indian Chemical Society, 1983 , vol. 60, # 8 p. 772 - 774
反应条件
1: SOCl2
2: ethanol / 6 h / Heating
View Scheme
参考文献
Dash; Patra; Mahapatra
Journal of the Indian Chemical Society, 1983 , vol. 60, # 8 p. 772 - 774
反应条件
1: ytterbium trichloride / ethanol / |Reflux
2: dihydrogen peroxide / ethanol / 0.5 h / |Reflux
View Scheme
参考文献
Fan, Liyan; Chen, Wen; Qian, Changtao
Tetrahedron Letters, 2013 , vol. 54, # 3 p. 231 - 234
反应条件
1: ytterbium trichloride / ethanol / |Reflux
2: dihydrogen peroxide / ethanol / 0.5 h / |Reflux
3: potassium hydroxide / methanol / 2 h / 20 °C / |Reflux
View Scheme
参考文献
Fan, Liyan; Chen, Wen; Qian, Changtao
Tetrahedron Letters, 2013 , vol. 54, # 3 p. 231 - 234
反应条件
1: 59 percent / DBU / dimethylformamide
2: 98 percent / KCN / dimethylformamide / 0.5 h / Ambient temperature
View Scheme
参考文献
Miyashita; Suzuki; Okumura; Higashino
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 252 - 254
反应条件
hydrogenchloride; sodium borohydride in 2,2,4-trimethylpentane; ethanol; chloroform; acetone
参考文献
A. H. Robins Company, Incorporated
Patent: US4803200 A1, 1989 ;
参考文献
A. H. Robins Company, Incorporated
Patent: US4803200 A1, 1989 ;
反应条件
trimethylsilyl iodide in chloroform
3 h;
参考文献
Krepski, Larry R.; Heilmann, Steven M.; Rasmussen, Jerald K.; Tumey, Michael L.; Smith, Howell K.
Synthetic Communications, 1986 , vol. 16, # 4 p. 377 - 386
