1: (3-iodophenyl)-(7-methoxymethyl-[1,4]-dioxano[2,3-g]quinazolin-4-yl)-amine With hydrogenchloride in acetonitrile T=70°C; 0.25 h; 2: With sodium nitrite in water; acetonitrile T=15°C; 0.25 h; 3: diethylamine With potassium carbonate in water; acetonitrile 0.166667 h; cooling;

1: 93 percent / copper iodide; bis(triphenylphosphine)palladium(II) chloride; triethylamine / 3 h / 30 °C 2: 85 percent / methyl iodide / 96 h / 110 °C 3: 80 percent / potassium hydroxide / methanol; CH2Cl2 / 2 h View Scheme