2-(4-甲氧苯基)噻吩合成路线 （共 72 条）
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; silver(l) oxide in methanol T=20°C; Suzuki-Miyaura cross- coupling; 1.5 h; Inert atmosphere;
参考文献
Botteselle, Giancarlo V.; Hough, Thomas L. S.; Venturoso, Raphael C.; Cella, Rodrigo; Vieira, Adriano S.; Stefani, Helio A.
Australian Journal of Chemistry, 2008 , vol. 61, # 11 p. 870 - 873
反应条件
1: 4-methoxyphenyl magnesium bromide With bismuth(III) chloride 2: thien-2-yl bromide With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
catalyst 1 (aliphatic, phosphine based pincer complex of palladium) in 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; 4 h;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 48 p. 12939 - 12941
反应条件
Pd0(tris(tert-butyl)phosphine)2 in N,N-dimethyl-formamide T=23 - 170°C; 0.141667 h; Microwave irradiation;
参考文献
Sevigny, Stephane; Forgione, Pat
Chemistry - A European Journal, 2013 , vol. 19, # 7 p. 2256 - 2260
反应条件
1: thiophene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; cobalt(II) dibromide in tetrahydrofuran; hexane T=0 - 20°C; 0.5 h; 2: para-iodoanisole in tetrahydrofuran; hexane T=20°C; 2 h; 3: With water in tetrahydrofuran; hexane
参考文献
Dayaker, Gandrath; Chevallier, Floris; Gros, Philippe C.; Mongin, Florence
Tetrahedron, 2010 , vol. 66, # 46 p. 8904 - 8910
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=110°C; 24 h;
参考文献
Hamad Elgazwy, Abdel-Sattar S.
Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 164, p. 131 - 143
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in water T=85°C; Suzuki Coupling; 3 h; Inert atmosphere;
参考文献
Reddy, Vutukuri Prakash; Qiu, Renhua; Iwasaki, Takanori; Kambe, Nobuaki
Organic Letters, 2013 , vol. 15, # 6 p. 1290 - 1293
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex in toluene T=80°C; 24 h;
参考文献
Denmark, Scott E.; Baird, John D.
Organic Letters, 2006 , vol. 8, # 4 p. 793 - 795
反应条件
1: thiophene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; CdCl2*TMEDA in tetrahydrofuran; hexane T=0 - 20°C; Inert atmosphere; 2: 1-bromo-4-methoxy-benzene With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate in tetrahydrofuran; hexane 18 h; Inert atmosphereReflux; chemoselective reaction;
参考文献
Snegaroff, Katia; L'Helgoual'ch, Jean-Martial; Bentabed-Ababsa, Ghenia; Nguyen, Tan Tai; Chevallier, Floris; Yonehara, Mitsuhiro; Uchiyama, Masanobu; Derdour, Aicha; Mongin, Florence
Chemistry - A European Journal, 2009 , vol. 15, # 39 p. 10280 - 10290
反应条件
potassium tert-butylate in dimethyl sulfoxide T=20°C; 3 h; Schlenk techniqueInert atmosphereIrradiation; TimeTemperatureConcentrationReagent/catalyst; Overall yield = 90 percent;
参考文献
Buden, Maria E.; Guastavino, Javier F.; Rossi, Roberto A.
Organic Letters, 2013 , vol. 15, # 6 p. 1174 - 1177
