2-(4-甲氧苯基)噻吩合成路线 （共 72 条）
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium methylate in chloroform 3 h; Ambient temperature;
参考文献
Kang, Suk-Ku; Choi, Sang-Chul; Baik, Tae-Gon
Synthetic Communications, 1999 , vol. 29, # 14 p. 2493 - 2499
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran T=-75°C; 1 h; Inert atmosphere; 2: With zinc(II) chloride−TMEDA in tetrahydrofuran T=-75 - 20°C; 3: 1-bromo-4-methoxy-benzene Further stages;
参考文献
Seggio, Anne; Jutand, Anny; Priem, Ghislaine; Mongin, Florence
Synlett, 2008 , # 19 p. 2955 - 2960
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; sodium methylate in chloroform 3 h; Ambient temperature;
参考文献
Kang, Suk-Ku; Choi, Sang-Chul; Baik, Tae-Gon
Synthetic Communications, 1999 , vol. 29, # 14 p. 2493 - 2499
反应条件
manganese triacetate Heating;
参考文献
Demir, Ayhan S.; Reis, Oemer; Emrullahoglu, Mustafa
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 578 - 580
反应条件
1: didodecanoyl peroxide / ethyl acetate / |Inert atmosphere; |Reflux 2: acetic acid; potassium iodide / 0.08 h / 110 °C / |Microwave irradiation View Scheme
参考文献
Jullien, Helene; Quiclet-Sire, Beatrice; Tetart, Thomas; Zard, Samir Z.
Organic Letters, 2014 , vol. 16, # 1 p. 302 - 305
反应条件
1-methyl-pyrrolidin-2-one; manganese bromide tetrahydrate; potassium fluoride; para-iodoanisole T=100°C; 8 h; other reagents: p-iodoanisole/CuI/KF, p-iodoanisole/CuI/CsF, p-iodoanisole/MnBr2/LiCl, p-iodoanisole/MnBr2/CsF, iodobenzene/CuI/NaCl;
参考文献
Kang, Suk-Ku; Kim, Jae-Sun; Choi, Sang-Chul
Journal of Organic Chemistry, 1997 , vol. 62, # 13 p. 4208 - 4209
反应条件
triphenylphosphine; Pd bipyridyl anchored nanosized mesoporous silica MCM-41 in tetrahydrofuran Kumada-Corriu reaction; 18 h; Heating;
参考文献
Tsai, Fu-Yu; Lin, Bo-Nan; Chen, Ming-Jie; Mou, Chung-Yuan; Liu, Shiuh-Tzung
Tetrahedron, 2007 , vol. 63, # 20 p. 4304 - 4309
反应条件
triphenylphosphine; Pd bipyridyl anchored nanosized mesoporous silica MCM-41 in tetrahydrofuran Kumada-Corriu reaction; 12 h; Heating;
参考文献
Tsai, Fu-Yu; Lin, Bo-Nan; Chen, Ming-Jie; Mou, Chung-Yuan; Liu, Shiuh-Tzung
Tetrahedron, 2007 , vol. 63, # 20 p. 4304 - 4309
反应条件
1: 4-MeOC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran T=25°C; 0.25 h; Inert atmosphere; 2: thien-2-yl bromide With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
1: thiophen-2-yl-MgX, X = halide With zinc(II) chloride in tetrahydrofuran T=25°C; 0.25 h; Inert atmosphere; 2: 1-bromo-4-methoxy-benzene With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
