2-(4-甲基-1-哌嗪)-4-喹唑啉乙酰胺合成路线 （共 3 条）
反应条件
in 1-methyl-pyrrolidin-2-one
T=60°C; 0.5 h; Inert atmosphere;
参考文献
ABBOTT LABORATORIES
Patent: US2011/152243 A1, 2011 ;
Location in patent: Page/Page column 47-48 ;
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere
1.2: 1 h / 110 °C
2.1: ammonium hydroxide / ethanol / 23.5 h / 20 - 50 °C
3.1: 1-methyl-pyrrolidin-2-one / 0.5 h / 60 °C / Inert atmosphere
View Scheme
参考文献
ABBOTT LABORATORIES
Patent: US2011/152243 A1, 2011 ;
反应条件
1.1: N,N-dimethyl-aniline; trichlorophosphate / 3 h / 110 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
2.2: 0.5 h / 110 °C / Inert atmosphere
3.1: 1-methyl-pyrrolidin-2-one / 0.75 h / 50 °C / Inert atmosphere
View Scheme
参考文献
Wagner, Juergen; Von Matt, Peter; Faller, Bernard; Cooke, Nigel G.; Albert, Rainer; Sedrani, Richard; Wiegand, Hansjoerg; Jean, Christian; Beerli, Christian; Weckbecker, Gisbert; Evenou, Jean-Pierre; Zenke, Gerhard; Cottens, Sylvain
Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 6028 - 6039
