2-[4-[3-[2,5-二氢-1-[(4-甲基苯基)甲基]-5-氧代-1H-1,2,4-T噻唑-3-基]丙基]苯氧基]-2-甲基-丙酸合成路线 （共 23 条）
反应条件
1: ethyl acetate / 20 °C
2: hydrogen; platinum(IV) oxide / tetrahydrofuran / 16 h / 20 °C / 2828.7 Torr
3: isopropyl alcohol / 16 h / 20 °C
4: toluene-4-sulfonic acid / toluene / 4 h / |Reflux
View Scheme
参考文献
Braden, Timothy M.; Coffey, D. Scott; Doecke, Christopher W.; LeTourneau, Michael E.; Martinelli, Michael J.; Meyer, Christopher L.; Miller, Richard D.; Pawlak, Joseph M.; Pedersen, Steven W.; Schmid, Christopher R.; Shaw, Bruce W.; Staszak, Michael A.; Vicenzi, Jeffrey T.
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 431 - 440
反应条件
1.1: 86.7 percent / boron tribromide / CH2Cl2 / 0.5 h / 5 °C
2.1: sodium hydroxide / 20 °C
2.2: -15 - 20 °C
View Scheme
参考文献
Kou, Fengjiun; Clodfelter, Dean K.; Farid, Nagy A.; Wheeler, William J.; Mckendry, Lennon H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 8 p. 693 - 701
反应条件
1: 5-[3-(4-hydroxyphenyl)propyl]-2-(4-methylbenzyl)-2,4-dihydro-[1,2,4]triazol-3-one; acetone With sodium hydroxide
T=20°C;
2: chloroform T=-15 - 20°C; Further stages.;
参考文献
Kou, Fengjiun; Clodfelter, Dean K.; Farid, Nagy A.; Wheeler, William J.; Mckendry, Lennon H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 8 p. 693 - 701
