9-苄基-9h-嘌呤-6-胺合成路线 （共 43 条）
反应条件
1.1: 90 percent / TFA / 5 h / Heating 2.1: MeONa / methanol / 0.33 h / 0 °C 2.2: 70 percent / anilinium chloride / 20 h / 20 °C View Scheme
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.; Burnett, Friedrich N.
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 382 - 386
反应条件
1: 92 percent / hydrazine monohydrate / methanol / 0.08 h 2: H2 / Raney Ni / ethanol / 18 h / 2275.5 Torr View Scheme
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.; Burnett, Friedrich N.
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 382 - 386
反应条件
1: 47 percent / trifluoroacetic acid / toluene; methanol / 72 h / Heating 2: 84 percent / trifluoroacetic acid / 4 h / Heating 3: 92 percent / hydrazine monohydrate / methanol / 0.08 h 4: H2 / Raney Ni / ethanol / 18 h / 2275.5 Torr View Scheme
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.; Burnett, Friedrich N.
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 382 - 386
反应条件
1: 88 percent / acetonitrile / 12 h / Ambient temperature 2: 84 percent / trifluoroacetic acid / 4 h / Heating 3: 92 percent / hydrazine monohydrate / methanol / 0.08 h 4: H2 / Raney Ni / ethanol / 18 h / 2275.5 Torr View Scheme
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.; Burnett, Friedrich N.
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 382 - 386
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in N,N-dimethyl-formamide T=120°C; 14 h;
参考文献
Yu, Xue-Jun; Liu, Wei; Hu, Wei-Dong; Dong, Xue-Liang; Xu, Dan; Deng, You-Quan
Journal of Chemical Research, 2007 , # 6 p. 347 - 349
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in N,N-dimethyl-formamide T=120°C; 14 h;
参考文献
Yu, Xue-Jun; Liu, Wei; Hu, Wei-Dong; Dong, Xue-Liang; Xu, Dan; Deng, You-Quan
Journal of Chemical Research, 2007 , # 6 p. 347 - 349
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in N,N-dimethyl-formamide T=120°C; 14 h;
参考文献
Yu, Xue-Jun; Liu, Wei; Hu, Wei-Dong; Dong, Xue-Liang; Xu, Dan; Deng, You-Quan
Journal of Chemical Research, 2007 , # 6 p. 347 - 349
反应条件
1: 46 percent / K2CO3 / dimethylformamide / 20 h / 20 °C 2: 65 percent / NH3 / methanol / 7 h / 90 °C View Scheme
参考文献
Laufer, Stefan A.; Domeyer, David M.; Scior, Thomas R. F.; Albrecht, Wolfgang; Hauser, Dominik R. J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 710 - 722
反应条件
1: 46 percent / K2CO3 / dimethylformamide / 20 h / 20 °C 2: 65 percent / NH3 / methanol / 7 h / 90 °C View Scheme
参考文献
Bourguignon; Desaubry; Raboisson; Wermuth; Lugnier
Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1768 - 1770
反应条件
copper(l) iodide; potassium carbonate in N,N,N',N',N'',N''-hexamethylphosphoric triamide; N,N-dimethyl-formamide T=175°C; 48 h; Yield givenYields of byproduct given;
参考文献
Cheng, Changmei; Shimo, Tetsuro; Somekawa, Kenichi; Baba, Masanori
Heterocycles, 1998 , vol. 48, # 3 p. 491 - 498
