2-(4-甲氧基苯基)咪唑并[1,2-a]吡啶-3-甲醛合成路线 （共 4 条）
反应条件
1: With trichlorophosphate
T=80°C; Vilsmeier Haack formylation; 12 h;
2: With water; sodium hydroxide
Vilsmeier Haack formylation;
参考文献
Lopez-Martinez, Margarita; Salgado-Zamora, Hector; San-Juan, Eduardo Ramirez; Zamudio, Sergio; Picazo, Ofir; Campos, Maria Elena; Naranjo-Rodriguez, Elia B.
Drug Development Research, 2010 , vol. 71, # 6 p. 371 - 381
反应条件
1: sodium hydrogencarbonate / ethanol / 5 h / |Reflux
2: trichlorophosphate / 1.5 h / 0 - 80 °C
View Scheme
参考文献
Khedar, Poonam; Pericherla, Kasiviswanadharaju; Kumar, Anil
Synlett, 2012 , vol. 23, # 18 p. 2609 - 2614,6
反应条件
1: N-bromosuccinmide; toluene-4-sulfonic acid / acetonitrile / 4 h / |Reflux
2: sodium hydrogencarbonate / ethanol / 5 h / |Reflux
3: trichlorophosphate / 1.5 h / 0 - 80 °C
View Scheme
参考文献
Khedar, Poonam; Pericherla, Kasiviswanadharaju; Kumar, Anil
Synlett, 2012 , vol. 23, # 18 p. 2609 - 2614,6
反应条件
1.1: acetone / |Reflux
2.1: hydrogenchloride / water / 1 h / |Reflux
3.1: trichlorophosphate / chloroform / 0 - 5 °C
3.2: 20 °C / |Reflux
View Scheme
参考文献
Kamal, Ahmed; Reddy, Vangala Santhosh; Karnewar, Santosh; Chourasiya, Sumit S.; Shaik, Anver Basha; Kumar, G. Bharath; Kishor, Chandan; Reddy, M. Kashi; Narasimha Rao; Nagabhushana, Ananthamurthy; Ramakrishna, Kallaganti V. S.; Addlagatta, Anthony; Kotamraju, Srigiridhar
ChemMedChem, 2013 , vol. 8, # 12 p. 2015 - 2025
