potassium acetate in tert-butyl alcohol T=90°C; 2 h; Inert atmosphere;

Pd[P(o-tol)3]2; CyPF-t-Bu; ammonia; sodium t-butanolate in 1,4-dioxane T=50°C; 24 h; Inert atmosphere;

1: dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; sodium carbonate / 1,4-dioxane; water / 24 h / Reflux 2: ethylenediamine / 1,4-dioxane; propan-1-ol; water / 24 h / Reflux View Scheme

potassium phosphate; palladium diacetate in N,N-dimethyl-formamide T=20°C; Suzuki-Miyaura coupling; 78 h;

1: phenyl-magnesium chloride With C24H52Cl2O12P4Pd2 in tetrahydrofuran; 1,4-dioxane T=20°C; Kumada-Corriu cross-coupling reaction; 0.0833333 h; Inert atmosphere; 2: 6-quinolinyl tosylate in tetrahydrofuran; 1,4-dioxane T=80°C; Kumada-Corriu cross-coupling reaction; 24 h; Inert atmosphere; regioselective reaction;

CM-phos; palladium diacetate; potassium carbonate in water; tert-butyl alcohol T=80°C; 18 h; Inert atmosphere;